ArticleNature reviews. Chemistry2018
Toward Generalization of Iterative Small Molecule Synthesis.
Article in Nature reviews. Chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Who cites it
43 citing papers in PubMed.
- A triple carbonylation cascade converts aldehydes into threofuranoses.Nature chemistry · 2026Article
- De novo synthesis of threofuranoses via a triple-carbonylation cascade of aldehydes.Nature chemistry · 2026Article
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- Mix-and-match synthesis of 3D small molecules.Nature · 2026Article
- Topology-controlled dynamic conjugated oligomers from tetra-arylsubstituted alkene building blocks.Nature communications · 2026Article
- Bench-Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal-Free Late-Stage Aziridination with Diverse Nitrogen Nucleophiles.Angewandte Chemie (International ed. in English) · 2026Article
- Considerations in Pursuing Reaction Scope Generality.Angewandte Chemie (International ed. in English) · 2025Review
- Automated Iterative N─C and C─C Bond Formation.Angewandte Chemie (International ed. in English) · 2025Article
- Enantioconvergent Chan-Lam Coupling: Synthesis of Chiral Benzylic Amides via Cu-Catalyzed Deborylative Amidation.Journal of the American Chemical Society · 2025Article
- Atom-by-Atom Iterative Synthetic Logic: Laying the Foundation for Programmable Automated Construction of Small Organic Molecules.ACS central science · 2025Review
- N-Acetylcysteine-Amide Protects Against Acute Acrylamide Neurotoxicity in Adult Zebrafish.Toxics · 2025Article
- AI-accelerated discovery of altermagnetic materials.National science review · 2025Article
- Photoenolization ofJournal of the American Chemical Society · 2025Article
- Refactoring the pikromycin synthase for the modular biosynthesis of macrolide antibiotics in E. coli.Research square · 2025Article
- Enantioconvergent Cross-Nucleophile Coupling: Copper-Catalyzed Deborylative Cyanation.Angewandte Chemie (International ed. in English) · 2024Article
- Article
- Photogeneration of α-Bimetalloid Radicals via Selective Activation of Multifunctional C1 Units.Journal of the American Chemical Society · 2024Article
- A Three-Step Catalytic Asymmetric Sequence from Alkynes to α-Silyloxyaldehydes and Its Application to a C22-C41 Fragment of Bastimolide A.Organic letters · 2024Article
- Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity.The Journal of organic chemistry · 2024Article
- Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers.Nature communications · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Small molecules have extensive untapped potential to benefit society, but access to this potential is too often restricted by limitations inherent to the customized approach currently used to synthesize this class of chemical matter. In contrast, the "building block approach", i.e., generalized iterative assembly of interchangeable parts, has now proven to be a highly efficient and flexible way to construct things ranging all the way from skyscrapers to macromolecules to artificial intelligence algorithms. The structural redundancy found in many small molecules suggests that they possess a similar capacity for generalized building block-based construction. It is also encouraging that many customized iterative synthesis methods have been developed that improve access to specific classes of small molecules. There has also been substantial recent progress toward the iterative assembly of many different types of small molecules, including complex natural products, pharmaceuticals, biological probes, and materials, using common building blocks and coupling chemistry. Collectively, these advances suggest that a generalized building block approach for small molecule synthesis may be within reach.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.