ArticleFrontiers in immunology2018
Overinterpretation and Overtreatment of Low-Titer Antibodies Against Contactin-Associated Protein-2.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Neuronal autoantibodies in neurodegenerative dementia: From evidence to clinical framework.The journal of prevention of Alzheimer's disease · 2026Review
- Autoimmune and infectious encephalitis: development of a discriminative tool for early diagnosis and initiation of therapy.Journal of neurology · 2024Article
- Clinical characteristics and long-term outcome of CASPR2 antibody-associated autoimmune encephalitis in children.Italian journal of pediatrics · 2024Article
- Anti-contactin-associated protein-like 2 antibody autoimmune encephalitis with rapidly progressive parkinsonism: a case report and literature review.Acta neurologica Belgica · 2023Review
- Case report: Autoimmune encephalitis associated with anti-CASPR2 antibody mimicking cerebral infarction.Frontiers in immunology · 2023Article
- Clinical Features and Outcomes in Pediatric Autoimmune Encephalitis Associated With CASPR2 Antibody.Frontiers in pediatrics · 2021Article
- Routine diagnostics for neural antibodies, clinical correlates, treatment and functional outcome.Journal of neurology · 2020Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibodies (abs) against neural or glial antigens have become important diagnostic markers of autoimmune encephalitides. A key requirement for interpretation of any test in clinical medicine is specificity. In this work, a 35-year-old female patient with low-titer contactin-associated protein-2 abs not satisfying clinical criteria of autoimmune encephalitis is reported. The patient had a recurrent depressive disorder and, at the time of the ab study, a moderate depressive episode. Overinterpretation and misinterpretation of patient's complaints and paraclinical study results fueled the idea of an autoimmune encephalitis. It is suggested to check patients with supposedly positive ab test results critically for clinical criteria, titer cutoffs, and ab-typical epidemiological features like age and sex.
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