ArticleFrontiers in aging neuroscience2018
Altered Functional Connectivity of Insular Subregions in Alzheimer's Disease.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Article
- Parallel multilink group joint ICA (pmg-jICA): Fusion of 3D structural and 4D functional data across multiple resting fMRI networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Review
- The association between fronto-insular interaction and executive function during childhood and adolescence in a resting state fMRI study.Scientific reports · 2025Article
- Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Regional brain structural alterations in reward and salience networks in asthma.Brain, behavior, and immunity · 2025Article
- The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Distinct brain activity patterns associated with traditional Chinese medicine syndromes: a task-fMRI study of mild cognitive impairment.Frontiers in neuroscience · 2025Article
- Increased anterior insula connectivity associated with cognitive maintenance in amnestic mild cognitive impairment: a longitudinal study.Brain imaging and behavior · 2024Article
- Evolutionarily conserved neural responses to affective touch in monkeys transcend consciousness and change with age.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring morphological similarity and randomness in Alzheimer's disease using adjacent grey matter voxel-based structural analysis.Alzheimer's research & therapy · 2024Article
- The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity.CNS neuroscience & therapeutics · 2024Article
- Distinct resting-state functional connectivity patterns of Anterior Insula affected by smoking in mild cognitive impairment.Brain imaging and behavior · 2023Article
- Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Identifying vulnerable brain networks associated with Alzheimer's disease risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age Related Functional Connectivity Signature Extraction Using Energy-Based Machine Learning Techniques.Sensors (Basel, Switzerland) · 2023Article
- Deep Learning for Brain MRI Confirms Patterned Pathological Progression in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Functional connectivity gradients of the insula to different cerebral systems.Human brain mapping · 2023Article
- Association of functional connectivity of the executive control network or default mode network with cognitive impairment in older adults with remitted major depressive disorder or mild cognitive impairment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment.Neural plasticity · 2023Article
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Authors and funding
9 authors.
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Abstract
Recent researches have demonstrated that the insula is the crucial hub of the human brain networks and most vulnerable region of Alzheimer's disease (AD). However, little is known about the changes of functional connectivity of insular subregions in the AD patients. In this study, we collected resting-state functional magnetic resonance imaging (fMRI) data including 32 AD patients and 38 healthy controls (HCs). By defining three subregions of insula, we mapped whole-brain resting-state functional connectivity (RSFC) and identified several distinct RSFC patterns of the insular subregions: For positive connectivity, three cognitive-related RSFC patterns were identified within insula that suggest anterior-to-posterior functional subdivisions: (1) an dorsal anterior zone of the insula that exhibits RSFC with executive control network (ECN); (2) a ventral anterior zone of insula, exhibits functional connectivity with the salience network (SN); (3) a posterior zone along the insula exhibits functional connectivity with the sensorimotor network (SMN). In addition, we found significant negative connectivities between the each insular subregion and several special default mode network (DMN) regions. Compared with controls, the AD patients demonstrated distinct disruption of positive RSFCs in the different network (ECN and SMN), suggesting the impairment of the functional integrity. There were no differences of the positive RSFCs in the SN between the two groups. On the other hand, several DMN regions showed increased negative RSFCs to the sub-region of insula in the AD patients, indicating compensatory plasticity. Furthermore, these abnormal insular subregions RSFCs are closely correlated with cognitive performances in the AD patients. Our findings suggested that different insular subregions presented distinct RSFC patterns with various functional networks, which are differently affected in the AD patients.
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