Evidence map›Paper›PMID 29695903›Full record

ArticleInternational journal of nanomedicine2018

Dual-responsive dithio-polydopamine coated porous CeO

Ying Zhang, Xiaowen Wu, Chenxi Hou, Kun Shang, Kui Yang, Zhimin Tian, Zhichao Pei, Yongquan Qu, Yuxin Pei

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying Zhang *Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Xiaowen Wu *Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Chenxi HouShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Kun ShangShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Kui YangShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Zhimin TianCenter for Applied Chemical Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China.
Zhichao PeiShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Yongquan QuCenter for Applied Chemical Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China.
Yuxin PeiShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
North West Agriculture and Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery.

methodsA multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO

resultsThe multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells. It also showed a dual-responsive property of glutathione and pH, achieving controllable drug release from the cleavage of disulfide bond and subsequent degradation of PDS in cancer cells. Moreover, the degradation of PDS led to the exposure of CeO

conclusionThis work presents a good example of a rational design towards synergistic and targeted DDS for cancer chemotherapies.

Indexed as

Antineoplastic AgentsAsialoglycoprotein ReceptorCeriumDoxorubicinDrug Delivery SystemsDrug LiberationDrug SynergismGlutathioneHEK293 CellsHep G2 CellsHumansHydrogen-Ion ConcentrationIndolesLactoseNanotubesPolymerizationAntineoplastic AgentsAsialoglycoprotein Receptorceric oxideCeriumDoxorubicinGlutathioneIndolesLactosepolydopaminePolymerscerium oxide nanoparticlesdegradable polydopaminedual-responsivenesssynergistic anticancertargeted drug delivery

Identifiers

PMID29695903
PMCPMC5905827
OpenAlexW2797170075

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.