ArticleBulletin of the World Health Organization2018
Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia.
Article in Bulletin of the World Health Organization, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Multimorbidity and the risk of post-tuberculosis lung disease: a systematic review and meta-analysis.BMJ global health · 2026Pooled it
- Pooled it
- Quantifying non-adherence to anti-tuberculosis treatment due to early discontinuation: a systematic literature review of timings to loss to follow-up.BMJ open respiratory research · 2024Pooled it
- Impact of mental disorders on active TB treatment outcomes: a systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2020Pooled it
- Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review.Chronic respiratory diseasePooled it
- Cognitive-behavioral therapy on psychological stress and quality of life in subjects with pulmonary tuberculosis: a community-based cluster randomized controlled trial.BMC public health · 2022Trial
- Article
- Measurement of Tuberculosis treatment adherence: A methodological scoping review of observational studies.PLOS global public health · 2026Article
- Article
- Barriers to treatment adherence among patients with tuberculosis: a qualitative study of Pakistani nationals and Afghan refugees.BMJ open · 2025Article
- Article
- Methodologies for studying depression in persons living with tuberculosis: Protocol for a scoping review.PloS one · 2025Article
- Depressive episode and treatment outcomes in elderly individuals with tuberculosis: A prospective cohort study in Korea.PloS one · 2025Article
- Article
- Article
- Stigma, depression, and quality of life among people with pulmonary tuberculosis diagnosed through active and passive case finding in Nepal: a prospective cohort study.BMC global and public health · 2024Article
- Possible depression in new tuberculosis patients in the Free State province, South Africa.Southern African journal of infectious diseases · 2024Article
- Exploring Sex Differences in Risk Factors and Quality of Life Among Tuberculosis Patients in Herat, Afghanistan: A Case-Control Study.International journal of public health · 2024Article
- Stigma, depression, quality of life, and the need for psychosocial support among people with tuberculosis in Indonesia: A multi-site cross-sectional study.PLOS global public health · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between comorbid depression and tuberculosis treatment outcomes, quality of life and disability in Ethiopia.
methodsThe study involved 648 consecutive adults treated for tuberculosis at 14 primary health-care facilities. All were assessed at treatment initiation (i.e. baseline) and after 2 and 6 months. We defined probable depression as a score of 10 or above on the nine-item Patient Health Questionnaire. Data on treatment default, failure and success and on death were obtained from tuberculosis registers. Quality of life was assessed using a visual analogue scale and we calculated disability scores using the World Health Organization's Disability Assessment Scale. Using multivariate Poisson regression analysis, we estimated the association between probable depression at baseline and treatment outcomes and death.
resultsUntreated depression at baseline was independently associated with tuberculosis treatment default (adjusted risk ratio, aRR: 9.09; 95% confidence interval, CI: 6.72 to 12.30), death (aRR: 2.99; 95% CI: 1.54 to 5.78), greater disability (
conclusionUntreated depression in people with tuberculosis was associated with worse treatment outcomes, poorer quality of life and greater disability. Health workers should be given the support needed to provide depression care for people with tuberculosis.
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