ArticleMucosal immunology2019
A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.
Open access · bronzeAbstract read
In one paragraph
Article in Mucosal immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 60 citations in OpenAlex.
- A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition.The American journal of clinical nutrition · 2022Trial
- Role of gut microbiota metabolites in maintaining intestinal health and preventing weaning-associated diarrhea in piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Scurvy in a Patient with Crohn's Disease: A Case Report.Current rheumatology reviews · 2026Article
- Microbiota-dependent metabolites - New engine for T cell warriors.Gut microbes · 2025Review
- Microbial micronutrient sharing, gut redox balance and keystone taxa as a basis for a new perspective to solutions targeting health from the gut.Gut microbes · 2025Review
- Comparing alignment and de-novo approaches for gut microbiota metagenomic data analysis reveals differences in taxonomic resolution and novel functional insights.Scientific reports · 2025Article
- Vitamin-mediated interaction between the gut microbiome and mitochondria in depression: A systematic review-based integrated perspective.Brain, behavior, & immunity - health · 2024Review
- Microbiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation.Nature communications · 2024Article
- Article
- The Role of Gut Microbiota in Neuromyelitis Optica Spectrum Disorder.International journal of molecular sciences · 2024Review
- Vitamins as regulators of calcium-containing kidney stones - new perspectives on the role of the gut microbiome.Nature reviews. Urology · 2023Review
- Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease.Metabolites · 2023Review
- Review
- Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries.Seminars in immunopathology · 2022Review
- Metagenomic profile of the fecal microbiome of preterm infants consuming mother's own milk with bovine milk-based fortifier or infant formula: a cross-sectional study.The American journal of clinical nutrition · 2022Article
- The evolution of vitamin C biosynthesis and transport in animals.BMC ecology and evolution · 2022Article
- Food for thought - ILC metabolism in the context of helminth infections.Mucosal immunology · 2022Review
- Advances in Microbiome-Derived Solutions and Methodologies Are Founding a New Era in Skin Health and Care.Pathogens (Basel, Switzerland) · 2022Review
- Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics.Applied microbiology and biotechnology · 2022Review
- Targeting Immune Cell Metabolism in the Treatment of Inflammatory Bowel Disease.Inflammatory bowel diseases · 2021Review
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 1 country.
Yu-Ling ChangMolecular Biology IDP, University of California, Los Angeles, CA, 90095, USA.
Maura RossettiPathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Hera VlamakisThe Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
David CaseroPathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Gemalene SungaPathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Nicholas HarrePathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Shelley MillerPathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Romney HumphriesPathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA.
Thaddeus StappenbeckWashington University School of Medicine, St. Louis, MO, 63110, USA.
Kenneth W SimpsonCollege of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
R Balfour SartorCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Gary WuDepartment of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
James LewisCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Frederic BushmanDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Dermot P B McGovernThe F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Nita SalzmanDepartment of Pediatrics, Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
James BornemanDepartment of Plant Pathology and Microbiology, University of California, Riverside, CA, 92521, USA.
Ramnik XavierThe Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Curtis HuttenhowerThe Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Jonathan BraunPathology and Laboratory Medicine, University of California, Los Angeles, CA, 90095, USA. jbraun@mednet.ucla.edu.
University of California, Los Angeles · USBroad Institute · USUniversity of Pennsylvania · USCedars-Sinai Medical Center · USCornell University · USMedical College of Wisconsin · USUniversity of California, Riverside · USUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · US
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MUsing polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1MRole of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEIKH, SHEHZAD Z. · 2013 to 2023
$17.9MNational Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7MRegulatory B Cells in Mucosal Homeostasis and IBDR01DK069434 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAUN, JONATHAN · 2005 to 2010
$1.3MAcquisition of a Scalable Storage Cluster for Data Intensive NIH ResearchS10OD016290 · OD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GIRKE, THOMAS · 2014 to 2014
$593kMechanisms of Intestinal Inflammation - Associated Systemic GenotoxicityR56AI094756 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAUN, JONATHAN, SCHIESTL, ROBERT H · 2012 to 2012
$378kNCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA016042NIAID NIH HHS R56 AI094756NIDDK NIH HHS P01 DK046763NIDDK NIH HHS P01 DK094779NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK069434NIH HHS P40 OD010995NIH HHS S10 OD016290
Abstract
Microbial metabolites are an emerging class of mediators influencing CD4
Indexed as
ApoptosisAscorbic AcidCell DifferentiationCell RespirationCells, CulturedCrohn DiseaseEnergy MetabolismHumansInterferon-gammaInterleukin-17Interleukin-4Lymphocyte ActivationMass ScreeningMicrobiotaTh17 CellsAscorbic AcidInterferon-gammaInterleukin-17Interleukin-4
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.