ArticleScientific reports2018
Deletion at the 5'-end of Estonian ASFV strains associated with an attenuated phenotype.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed.
- MGF100 but not MGF300 family is a potential multigene-deleted target for ASFV attenuation and live attenuated vaccine development.Virulence · 2026Article
- Genetically Distinct African Swine Fever Virus Genotype II Variant in Wild Boar, Spain, 2025-2026.Emerging infectious diseases · 2026Article
- MGF110-2L deletion prevents IFN-I and inflammatory response, resulting in partial attenuation and protection against virulent ASFV.Journal of virology · 2026Article
- Correlates of protection against African swine fever virus identified by a systems immunology approach.eLife · 2026Article
- Genome sequencing reveals a highly divergent Biotype II African swine fever virus in Nigeria.Research square · 2026Article
- Duration of immunity following infection with moderately virulent ASFV.PLoS pathogens · 2026Article
- Genome sequencing reveals variation of African swine fever virus in Nigerian outbreaks and identification of two major West African viral lineages.Microbial genomics · 2026Article
- Comparative evaluation of histopathological lesions and viral antigen distribution in domestic pigs and wild boar inoculated intranasally with the highly virulent ASFV genotype II strain "Armenia 2007".Veterinary research · 2026Article
- How the wild things are: comparative T cell phenotyping and memory T cell identification in wild boar and domestic pigs.Frontiers in immunology · 2026Article
- Infection of the Conceptus With African Swine Fever Virus Following Artificial Insemination in Sows: A Pathological Study.Transboundary and emerging diseases · 2026Article
- Dynamics of leukocyte populations, immune-regulatory cytokines, and biochemical parameters in wild boar and domestic pigs experimentally infected with a virulent African swine fever virus genotype II strain.Frontiers in immunology · 2026Article
- Article
- Changes in saliva and serum analytes in domestic pigs and wild boar experimentally infected with African swine fever virus.Veterinary research · 2025Article
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- African swine fever virus biotype identification tool.Microbiology resource announcements · 2025Article
- Exploring antiviral strategies to combat African swine fever.FEMS microbiology reviews · 2025Review
- Genome-Wide Approach Identifies Natural Large-Fragment Deletion in ASFV Strains Circulating in Italy During 2023.Pathogens (Basel, Switzerland) · 2025Article
- Safety of Live Attenuated ASFV-G-ΔI177L/ΔLVR Vaccination in Sows With Advanced Pregnancies.Transboundary and emerging diseases · 2025Article
- Maternal immunity and African swine fever virus: understanding the limits of passive protection.Frontiers in immunology · 2025Article
- Safe and efficient transportation of clinical samples for molecular detection of African swine fever virus.Frontiers in cellular and infection microbiology · 2025Article
48 more citing papers are in PubMed but not listed here.
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13 authors.
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Abstract
African swine fever (ASF) was introduced into the Eastern European Union in 2014 and led to considerable mortality among wild boar. In contrast, unexpected high antibody prevalence was reported in hunted wild boar in north-eastern Estonia. One of the causative virus strains was recently characterized. While it still showed rather high virulence in the majority of experimentally infected animals, one animal survived and recovered completely. Here, we report on the follow-up characterization of the isolate obtained from the survivor in the acute phase of infection. As a first step, three in vivo experiments were performed with different types of pigs: twelve minipigs (trial A), five domestic pigs (trial B), and five wild boar (trial C) were inoculated. 75% of the minipigs and all domestic pigs recovered after an acute course of disease. However, all wild boar succumbed to infection within 17 days. Representative samples were sequenced using NGS-technologies, and whole-genomes were compared to ASFV "Georgia 2007/1". The alignments indicated a deletion of 14560 base pairs at the 5' end, and genome reorganization by duplication. The characteristic deletion was confirmed in all trial samples and local field samples. In conclusion, an ASFV variant was found in Estonia that showed reduced virulence.
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