Evidence map›Paper›PMID 29695786›Full record

ArticleNature cell biology2018

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.

Yunfang Zhang, Xudong Zhang, Junchao Shi, Francesca Tuorto, Xin Li, Yusheng Liu, Reinhard Liebers, Liwen Zhang, Yongcun Qu, Jingjing Qian and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed, 2 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 2 syntheses or guidelines pooled it, 481 citations in OpenAlex.

  1. Pooled it
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  13. Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 4 institutions in 3 countries.

Yunfang ZhangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-9529-0431
Xudong ZhangDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID http://orcid.org/0000-0002-5964-0067
Junchao ShiDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID http://orcid.org/0000-0002-1548-5069
Francesca TuortoDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1625-1181
Xin LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yusheng LiuState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Reinhard LiebersDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.
Liwen ZhangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yongcun QuState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Jingjing QianState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Maya PahimaDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Ying LiuDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Menghong YanKey Laboratory of Nutrition and Metabolism, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Zhonghong CaoState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xiaohua LeiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yujing CaoState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Hongying PengDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Shichao LiuDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Yue WangDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Huili ZhengDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Rebekah WoolseyNevada Proteomics Center, University of Nevada, Reno School of Medicine, Reno, NV, USA.
David QuiliciNevada Proteomics Center, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Qiwei ZhaiKey Laboratory of Nutrition and Metabolism, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Lei LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-5478-5681
Tong ZhouDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Wei YanDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Frank LykoDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4873-5431
Ying ZhangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. zhangying@ioz.ac.cn.ORCID http://orcid.org/0000-0003-4082-5026
Qi ZhouState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qzhou@ioz.ac.cn.ORCID http://orcid.org/0000-0002-6549-9362
Enkui DuanState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. duane@ioz.ac.cn.ORCID http://orcid.org/0000-0002-2721-635X
Qi ChenDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA. cqi@med.unr.edu.ORCID http://orcid.org/0000-0001-6353-9589
University of Nevada, Reno · USChinese Academy of Sciences · CNGerman Cancer Research Center · DEShandong University of Technology · CN

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI ASTER SIGEL · 2012 to 2026
$58.0M
Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Sperm tsRNAs/rsRNAs and their RNA modifications in diet-induced epigenetic inheritanceR01HD092431 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Qi Chen, David S Milstone · 2017 to 2026
$3.5M
Regulation of Spermatogenesis by X-linked miRNAsR01HD060858 · NICHD · UNIVERSITY OF NEVADA RENO · PI MCCARREY, JOHN R, YAN, WEI · 2010 to 2014
$2.0M
Messenger RNA Fate Control in SpermatogenesisR01HD085506 · NICHD · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2015 to 2019
$1.5M
NICHD NIH HHS R01 HD060858NICHD NIH HHS R01 HD085506NICHD NIH HHS R01 HD092431NIGMS NIH HHS P20 GM103440NIGMS NIH HHS P30 GM110767
6 · The paper itself

Abstract

The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional paternal information aside from solely providing the DNA

Indexed as

Paternal InheritanceAnimalsBiomarkersBlood GlucoseDiet, High-FatDNA (Cytosine-5-)-MethyltransferasesEpigenesis, GeneticGene-Environment InteractionGene Expression Regulation, DevelopmentalGenetic Predisposition to DiseaseGlucose Metabolism DisordersHeredityInsulinMaleMiceMice, Inbred C57BLBiomarkersBlood GlucoseDNA (Cytosine-5-)-MethyltransferasesDnmt2 protein, mouseInsulinRNA, Small Untranslated

Identifiers

PMID29695786
PMCPMC5926820
OpenAlexW2802402149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.