Evidence map›Paper›PMID 29695724›Full record

ArticleScientific reports2018

Simultaneous lancet-free monitoring of alcohol and glucose from low-volumes of perspired human sweat.

Ashlesha Bhide, Sriram Muthukumar, Amreek Saini, Shalini Prasad

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  9. Wearable biosensors for human fatigue diagnosis: A review.Bioengineering & translational medicine · 2023
    Review
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  11. Review
  12. Review
  13. Article
  14. Article
  15. The Application of Wearable Glucose Sensors in Point-of-Care Testing.Frontiers in bioengineering and biotechnology · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ashlesha BhideDepartment of Bioengineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX, 75080, USA.
Sriram MuthukumarEnlisense LLC, 1813 Audubon Pond way, Allen, TX, 75013, USA.
Amreek SainiDepartment of Bioengineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX, 75080, USA.
Shalini PrasadDepartment of Bioengineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX, 75080, USA. shalini.prasad@utdallas.edu.ORCID 0000-0002-2404-3801

Funding

AWARE (A Wearable Awareness with Real-time Exposure): Rapid Wearable Alcohol DiagnosticsR43AA026114 · NIAAA · ENLISENSE, LLC · PI MUTHUKUMAR, SRIRAM · 2017 to 2017
$242k
NIAAA NIH HHS R43 AA026114
6 · The paper itself

Abstract

A lancet-free, label-free biosensor for simultaneous detection of sweat glucose and alcohol was demonstrated using zinc oxide thin films integrated into a nanoporous flexible electrode system. Sensing was achieved from perspired human sweat at low volumes (1-3 μL), comparable to ambient conditions without external stimulation. Zinc oxide thin film electrodes were surface functionalized with alcohol oxidase enzyme and with glucose oxidase enzyme towards developing an affinity biosensor specific to the physiological relevant range of alcohol comprising of 0-2 drinks (0-50 mg/dl) and physiologically relevant range of glucose ranging from hypo- to hyper-glycaemia (50-130 mg/dl) in perspired human sweat. Sensing was achieved by measuring impedance changes associated with alcohol and glucose binding onto the sensor interface using electrochemical impedance spectroscopy with a dynamic range from 0.01-200 mg/dl and a limit of detection of 0.01 mg/dl for alcohol in human sweat. Sensor calibration in synthetic sweat containing interferents (25-200 mg/dl) and comparison using regression and Bland-Altman analysis of sweat sensor performance was done with BACtrack

Indexed as

Biosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringDielectric SpectroscopyElectric ImpedanceElectrochemical TechniquesElectrodesEthanolGlucoseGlucose OxidaseHumansSweatWearable Electronic DevicesZinc OxideBlood GlucoseEthanolGlucoseGlucose OxidaseZinc Oxide

Identifiers

PMID29695724
PMCPMC5916883

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.