Evidence map›Paper›PMID 29695630›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

CRISPR/Cas9-mediated genome editing in a reef-building coral.

Phillip A Cleves, Marie E Strader, Line K Bay, John R Pringle, Mikhail V Matz

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 163 citations in OpenAlex.

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  18. Role of the bicarbonate transporter SLC4γ in stony-coral skeleton formation and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Small RNAs in Cnidaria: A review.Evolutionary applications · 2023
    Article
  20. Network-level containment of single-species bioengineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Phillip A ClevesDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Marie E StraderDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712.
Line K BayAustralian Institute of Marine Science, Townsville, QLD 4810, Australia.
John R PringleDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305; jpringle@stanford.edu matz@utexas.edu.
Mikhail V MatzDepartment of Integrative Biology, The University of Texas at Austin, Austin, TX 78712; jpringle@stanford.edu matz@utexas.edu.ORCID 0000-0001-5453-9819
Stanford University · USThe University of Texas at Austin · USAustralian Institute of Marine Science · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reef-building corals are critically important species that are threatened by anthropogenic stresses including climate change. In attempts to understand corals' responses to stress and other aspects of their biology, numerous genomic and transcriptomic studies have been performed, generating a variety of hypotheses about the roles of particular genes and molecular pathways. However, it has not generally been possible to test these hypotheses rigorously because of the lack of genetic tools for corals. Here, we demonstrate efficient genome editing using the CRISPR/Cas9 system in the coral

Indexed as

Coral ReefsCRISPR-Cas SystemsGene EditingMutationAnimalsBase SequenceFibroblast Growth Factor 1GenomeGenomicsGreen Fluorescent ProteinsLuminescent ProteinsPhenotypeRed Fluorescent ProteinSequence HomologyFibroblast Growth Factor 1Green Fluorescent ProteinsLuminescent ProteinsRed Fluorescent ProteinAcropora milleporacoralCRISPR/Cas9genome editing

Identifiers

PMID29695630
PMCPMC5960312
OpenAlexW2800368920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.