Evidence map›Paper›PMID 29695624›Full record

ArticlemSphere2018

New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi.

Valmik K Vyas, G Guy Bushkin, Douglas A Bernstein, Matthew A Getz, Magdalena Sewastianik, M Inmaculada Barrasa, David P Bartel, Gerald R Fink

Abstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. EditingBiomolecules · 2026
    Review
  5. International journal of molecular sciences · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. microPublication biology · 2025
    Article
  13. Article
  14. Article
  15. mSphere · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Rational evolution for altering the ligand preference of estrogen receptor alpha.Protein science : a publication of the Protein Society · 2024
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valmik K VyasWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
G Guy BushkinWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
Douglas A BernsteinWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
Matthew A GetzWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
Magdalena SewastianikWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
M Inmaculada BarrasaWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
David P BartelWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
Gerald R FinkWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA gfink@wi.mit.edu.

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Post-transcriptional gene regulationR35GM118135 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DAVID P BARTEL · 2016 to 2026
$10.7M
REGULATION OF HISTIDINE BIOSYNTHESIS IN YEASTR01GM035010 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI FINK, GERALD R · 1985 to 2016
$9.9M
Distinguishing features of C. albicans pseudouridylation and their roles in pathogenesisR15AI130950 · NIAID · BALL STATE UNIVERSITY · PI BERNSTEIN, DOUGLAS A. · 2017 to 2025
$1.4M
Roles for mRNA methylation and lncRNA in Candida mating and pathogenicityF32GM108201 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI BUSHKIN, GARY GUY · 2014 to 2016
$164k
NIAID NIH HHS R15 AI130950NIGMS NIH HHS F32 GM108201NIGMS NIH HHS R01 GM035010NIGMS NIH HHS R35 GM118135NIGMS NIH HHS T32 GM007287
6 · The paper itself

Abstract

We have created new vectors for clustered regularly interspaced short palindromic repeat (CRISPR) mutagenesis in

Indexed as

CRISPR-Cas SystemsDNA End-Joining RepairMutagenesisCandida albicansCandida glabrataDNA Breaks, Double-StrandedFungiGene EditingGenetic VectorsRNA, Guide, CRISPR-Cas SystemsSaccharomyces cerevisiaeRNA, Guide, CRISPR-Cas SystemsalbicansCandidacastelliicerevisiaeCRISPRglabrataNaumovozymaSaccharomyces

Identifiers

PMID29695624
PMCPMC5917429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.