ArticleMolecular systems biology2018
Timing of gene expression in a cell-fate decision system.
Article in Molecular systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
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- Kar4 acts as a Ste12 regulator inbioRxiv : the preprint server for biology · 2025Article
- Basal association of a transcription factor favors early gene expression.PLoS genetics · 2025Article
- A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations.Nature communications · 2025Article
- A multidimensional toolkit for elucidating temporal trajectories in cell development in vivo.Development (Cambridge, England) · 2024Article
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- Can the genes communicate with each other after birth? An international cross-sectional study.Health science reports · 2023Article
- M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter.International journal of molecular sciences · 2023Article
- Mechanism of commitment to a mating partner inMolecular biology of the cell · 2022Article
- Exploratory polarization facilitates mating partner selection inMolecular biology of the cell · 2021Article
- A rationally engineered decoder of transient intracellular signals.Nature communications · 2021Article
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- Stochastic fluctuations in apoptotic threshold of tumour cells can enhance apoptosis and combat fractional killing.Royal Society open science · 2020Article
- Ratiometric GPCR signaling enables directional sensing in yeast.PLoS biology · 2019Article
- Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies.Science (New York, N.Y.) · 2019Article
- Timing of gene expression in a cell-fate decision system.Molecular systems biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand this process. Pheromone secreted by the mating partner triggers the activity of a MAPK pathway, which results in the expression of hundreds of genes. Using a dynamic expression reporter, we quantified the kinetics of gene expression in single cells upon exogenous pheromone stimulation and in the physiological context of mating. In both conditions, we observed striking differences in the timing of induction of mating-responsive promoters. Biochemical analyses and generation of synthetic promoter variants demonstrated how the interplay between transcription factor binding and nucleosomes contributes to determine the kinetics of transcription in a simplified cell-fate decision system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.