ArticleNeurology2018
Brain pathology is related to total daily physical activity in older adults.
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Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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27citing papers in PubMed, 3 pooled it
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review.The Journal of frailty & aging · 2025Pooled it
- Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis.Journal of sport and health science · 2024Pooled it
- Trial
- Sex-specific effects of exercise on motor coordination and extended basal ganglia physiology.bioRxiv : the preprint server for biology · 2026Article
- Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025Review
- Association of Alzheimer's Disease and Other Neuropathologies With Functional Disability in Persons With and Without Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Correlated decline of cognitive and motor phenotypes and ADRD pathologies in old age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.Annals of neurology · 2023Article
- Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.Sensors (Basel, Switzerland) · 2023Article
- Article
- Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Motility Profile of Captive-Bred Marmosets Revealed by a Long-Term In-Cage Monitoring System.Frontiers in systems neuroscience · 2021Article
- Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain.Frontiers in aging neuroscience · 2021Review
- Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Aron S BuchmanFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada. Aron_S_Buchman@rush.edu.
Robert J DaweFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada.
Lei YuFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada.
Andrew LimFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada.
Robert S WilsonFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada.
Julie A SchneiderFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada.
David A BennettFrom the Rush Alzheimer's Disease Center (A.S.B., R.J.D., L.Y., R.S.W., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., L.Y., R.S.W., J.A.S., D.A.B.), Department of Radiology (R.J.D.), Department of Psychology (R.S.W.), and Department of Pathology (Neuropathology) (J.A.S.), Rush University Medical Center Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Ontario, Canada.
Rush University Medical Center · US
Funding
ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTAU, AB, SYNUCLEIN AND NITRATIVE/OXIDATIVE DAMAGE IN MCIP01AG014449 · NIA · UNIVERSITY OF PITTSBURGH · PI COUNTS, SCOTT E · 1997 to 2024
$39.7MRisk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2MHigher Precision Human and Mouse TranscriptomesUM1HG009443 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MORTAZAVI, SEYED ALI, WOLD, BARBARA J · 2017 to 2021
$15.5MPathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6MRecurrent Hemorrhagic Stroke in Minority PopulationsR01NS093870 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI JONATHAN ROSAND, Amytis Towfighi · 2016 to 2026
$12.3MAfrican Ancestry and the Genomic Architecture of AD and Other Common Neurodegenerative Disease NeuropathologiesR01AG054058 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2016 to 2023
$8.9MCharacterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8MDiscovery of Novel Proteomic Targets in Alzheimer's DiseaseU01AG046161 · NIA · EMORY UNIVERSITY · PI BENNETT, DAVID ALAN, GESCHWIND, DANIEL H · 2014 to 2018
$8.4MClinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1MNHGRI NIH HHS UM1 HG009443NIA NIH HHS P01 AG014449NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG033570NIA NIH HHS R01 AG033678NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG040039NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG043379NIA NIH HHS R01 AG046174NIA NIH HHS R01 AG047976NIA NIH HHS R01 AG048108NIA NIH HHS R01 AG050431NIA NIH HHS R01 AG050631NIA NIH HHS R01 AG051635NIA NIH HHS R01 AG052200NIA NIH HHS R01 AG052488NIA NIH HHS R01 AG053446NIA NIH HHS R01 AG054058NIA NIH HHS R01 AG056352NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG022018NIA NIH HHS RF1 AG036042NIA NIH HHS RF1 AG048056NIA NIH HHS RF1 AG051641NIA NIH HHS RF1 AG052476NIA NIH HHS RF1 AG054057NIA NIH HHS U01 AG029824NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIDDK NIH HHS R01 DK099269NINDS NIH HHS R01 NS078009NINDS NIH HHS R01 NS084965NINDS NIH HHS R01 NS086736NINDS NIH HHS R01 NS089674NINDS NIH HHS R01 NS093870NINDS NIH HHS UH2 NS100599
Abstract
objectiveTo test the hypothesis that brain pathology is associated with total daily physical activity proximate to death in older adults.
methodsWe studied brain autopsies from 428 decedents of the Rush Memory and Aging Project. The quantity of all physical activity was measured continuously for up to 10 days with actigraphy (Actical; Philips Healthcare, Bend, OR). Multiple regression analyses controlling for age and sex were used to examine the relation of brain indexes to total daily physical activity and other clinical covariates proximate to death.
resultsAverage total daily activity was 1.53 × 10
conclusionMacroinfarcts, nigral neuronal loss, and white matter pathologies are related to total daily physical activity in older adults, but further studies are needed to explain its pathologic basis more fully.
Indexed as
ExerciseAgedAged, 80 and overBrainFemaleHumansMagnetic Resonance ImagingMaleRegression AnalysisWhite Matter
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