Evidence map›Paper›PMID 29695508›Full record

ArticleThe Journal of biological chemistry2018

Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs.

Maria Fragiadaki, Martin P Zeidler

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  3. Downregulation ofTranslational cancer research · 2025
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  19. Review
  20. ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maria FragiadakiFrom the Academic Nephrology Unit, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, United Kingdom and m.fragiadaki@sheffield.ac.uk.
Martin P Zeidlerthe Bateson Centre, Departments of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.

Funding

Cancer Research UK
6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) represents the most common kidney cancer worldwide. Increased cell proliferation associated with abnormal microRNA (miRNA) regulation are hallmarks of carcinogenesis. Ankyrin repeat and single KH domain 1 (ANKHD1) is a highly conserved protein found to interact with core cancer pathways in

Indexed as

Cell ProliferationGene Expression Regulation, NeoplasticBinding SitesCarcinoma, Renal CellCase-Control StudiesCell MovementGene Expression ProfilingHumansKidney NeoplasmsMicroRNAsPrognosisRNA-Binding ProteinsTumor Cells, CulturedANKHD1 protein, humanMicroRNAsRNA-Binding ProteinsANKHD1cancer biologyccRCCcell proliferationclear cellkidneymicroRNA mechanismmicroRNA (miRNA)miR-29amiRNA-binding

Identifiers

PMID29695508
PMCPMC6016471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.