ArticleStroke2018
Population-Based Assessment of the Long-Term Risk of Seizures in Survivors of Stroke.
Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Common Pathways of Epileptogenesis in Patients With Epilepsy Post-Brain Injury: Findings From a Systematic Review and Meta-analysis.Neurology · 2023Pooled it
- Late epileptic seizures following cerebral venous thrombosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Smoking-cessation pharmacotherapy for patients with stroke and TIA: Systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Pooled it
- Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy.Clinical neurophysiology practice · 2026Review
- Associations of Stroke With Risk of Epilepsy: Results From the Atherosclerosis Risk in Communities (ARIC) Study.Annals of clinical and translational neurology · 2025Article
- Differences in patterns of outpatient epilepsy-specific medication initiation after acute ischemic stroke in the Medicare population.Epilepsia · 2025Observational
- Altered intrinsic thalamic network based on electroencephalography source-level analysis in poststroke epilepsy.Medicine · 2025Observational
- Predictive models for secondary epilepsy in patients with acute ischemic stroke within one year.eLife · 2024Article
- Ion Channel Dysregulation Following Intracerebral Hemorrhage.Neuroscience bulletin · 2024Review
- Post-stroke Everything.Current neurology and neuroscience reports · 2023Review
- Development and validation of a novel radiomics-clinical model for predicting post-stroke epilepsy after first-ever intracerebral haemorrhage.European radiology · 2023Article
- Long-term risk of seizure after posterior reversible encephalopathy syndrome.Annals of clinical and translational neurology · 2023Article
- Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis.Frontiers in neurology · 2022Article
- Risk of Developing Epilepsy after Autoimmune Encephalitis.Brain sciences · 2021Article
- Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage.JAMA neurology · 2021Article
- Anticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients: A Decision Analysis.Stroke · 2021Article
- Poststroke epilepsy incidence, risk factors and treatment: German claims analysis.Acta neurologica Scandinavica · 2021Article
- Risk of Post-stroke Epilepsy Following Stroke-Associated Acute Symptomatic Seizures.Frontiers in aging neuroscience · 2021Article
- Investigation of poststroke epilepsy (INPOSE) study: a multicenter prospective study for prediction of poststroke epilepsy.Journal of neurology · 2020Article
- [Epilepsy in old age].Der Nervenarzt · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeWe sought to determine the long-term risk of seizures after stroke according to age, sex, race, and stroke subtype.
methodsWe performed a retrospective cohort study using administrative claims from 2 complementary patient data sets. First, we analyzed data from all emergency department visits and hospitalizations in California, Florida, and New York from 2005 to 2013. Second, we evaluated inpatient and outpatient claims from a nationally representative 5% random sample of Medicare beneficiaries. Our cohort consisted of all adults at the time of acute stroke hospitalization without a prior history of seizures. Our outcome was seizure occurring after hospital discharge for stroke. Poisson regression and demographic data were used to calculate age-, sex-, and race-standardized incidence rate ratios (IRR).
resultsAmong 777 276 patients in the multistate cohort, the annual incidence of seizures was 1.68% (95% confidence interval [CI], 1.67%-1.70%) after stroke versus 0.15% (95% CI, 0.15%-0.15%) among the general population (IRR, 7.3; 95% CI, 7.3-7.4). By 8 years, the cumulative rate of any emergency department visit or hospitalization for seizure was 9.27% (95% CI, 9.16%-9.38%) after stroke versus 1.21% (95% CI, 1.21%-1.22%) in the general population. Stroke was more strongly associated with a subsequent seizure among patients <65 years of age (IRR, 12.0; 95% CI, 11.9-12.2) than in patients ≥65 years of age (IRR, 5.5; 95% CI, 5.4-5.5) and in the multistate analysis, the association between stroke and seizure was stronger among nonwhite patients (IRR, 11.0; 95% CI, 10.8-11.2) than among white patients (IRR, 7.3; 95% CI, 7.2-7.4). Risks were especially elevated after intracerebral hemorrhage (IRR, 13.3; 95% CI, 13.0-13.6) and subarachnoid hemorrhage (IRR, 13.2; 95% CI, 12.8-13.7). Our study of Medicare beneficiaries confirmed these findings.
conclusionsAlmost 10% of patients with stroke will develop seizures within a decade. Hemorrhagic stroke, nonwhite race, and younger age seem to confer the greatest risk of developing seizures.
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