ArticleCancer genomics & proteomics
Cytogenetics of Spindle Cell/Pleomorphic Lipomas: Karyotyping and FISH Analysis of 31 Tumors.
Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
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- Chromosome Translocation t(10;19)(q26;q13) in a CIC-sarcoma.In vivo (Athens, Greece)Article
- Recurrent 8q11-13 Aberrations Leading toCancer genomics & proteomicsArticle
- Fusion of the High-mobility Group AT-Hook 2 (In vivo (Athens, Greece)Article
- Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review.Cancer diagnosis & prognosisReview
- Fusion of the Genes for Interferon Regulatory Factor 2 Binding Protein 2 (In vivo (Athens, Greece)Article
- Fusion of the GenesCancer genomics & proteomicsArticle
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSpindle cell/pleomorphic lipomas are benign tumors. Here, we present our cytogenetic data on 31 such tumors. MATERIALS AND
methodsG-banding chromosome analysis and (in selected cases) fluorescence in situ hybridization (FISH) using probes for FOXO1, RB1, and HMGA2 were performed.
resultsRearrangements of chromosome 13 were found in 58% of tumors. Chromosomes 6, 1, 12, and 11 were also involved in 42%, 26%, 26%, and 23% of tumors, respectively. FISH analysis showed heterozygous deletion of RB1 in seven samples with chromosome 13 aberrations. In four of them, FOXO1 was also deleted. In two tumors with 12q15 rearrangements, FISH confirmed that HMGA2 was targeted.
conclusionStructural rearrangements of 13q or losses of an entire chromosome 13 are the most common cytogenetic aberrations in spindle cell/pleomorphic lipomas. However, cytogenetic variation exists similarly to what is found in other lipomas, suggesting that various pathways may be responsible for tumorigenesis.
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