ArticleGenome biology2018
Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish.
Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comprehensive machine learning assessment of zebrafish behaviour and biochemical markers in response to caffeine exposure.Ecotoxicology (London, England) · 2025Article
- Ecotoxicological Effects of Potassium Dichromate on the Tadpole ShrimpAnimals : an open access journal from MDPI · 2024Article
- A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.Nature communications · 2023Article
- Emergence of consistent intra-individual locomotor patterns during zebrafish development.Scientific reports · 2019Article
- Brain evolution in social insects: advocating for the comparative approach.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Review
- Widespread inter-individual gene expression variability inMolecular systems biology · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAnimals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model to test the influence of histone modifications on behavior.
resultsWe find that laboratory and isogenic zebrafish larvae show consistent individual behaviors when swimming freely in identical wells or in reaction to stimuli. This behavioral inter-individual variability is reduced when we impair the histone deacetylation pathway. Individuals with high levels of histone H4 acetylation, and specifically H4K12, behave similarly to the average of the population, but those with low levels deviate from it. More precisely, we find a set of genomic regions whose histone H4 acetylation is reduced with the distance between the individual and the average population behavior. We find evidence that this modulation depends on a complex of Yin-yang 1 (YY1) and histone deacetylase 1 (HDAC1) that binds to and deacetylates these regions. These changes are not only maintained at the transcriptional level but also amplified, as most target regions are located near genes encoding transcription factors.
conclusionsWe suggest that stochasticity in the histone deacetylation pathway participates in the generation of genetic-independent behavioral inter-individual variability.
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