Evidence map›Paper›PMID 29695254›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2018

Atherosclerosis T1-weighted characterization (CATCH): evaluation of the accuracy for identifying intraplaque hemorrhage with histological validation in carotid and coronary artery specimens.

Wen Liu, Yibin Xie, Chuan Wang, Yanni Du, Christopher Nguyen, Zhenjia Wang, Zhaoyang Fan, Li Dong, Yi Liu, Xiaoming Bi and 4 more

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. CMR publications from China of the last more than 30 years.The international journal of cardiovascular imaging · 2020
    Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Why high intensity plaque is bright on MRI?American heart journal plus : cardiology research and practice · 2021
    Article
  8. Article
  9. Review
  10. Relationship between coronary hyper-intensive plaques identified by cardiovascular magnetic resonance and clinical severity of acute coronary syndrome.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  11. Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Wen LiuDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yibin XieBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Chuan WangDepartment of Cardiac Surgery, Anzhen Hospital, Capital Medical University, Beijing, China.
Yanni DuDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Christopher NguyenCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Zhenjia WangDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Zhaoyang FanBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Li DongDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yi LiuDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Xiaoming BiMR R&D, Siemens Healthineers, Los Angeles, CA, USA.
Jing AnMR Collaborations NE Asia, Siemens Healthcare, Beijing, China.
Chengxiong GuDepartment of Cardiac Surgery, Anzhen Hospital, Capital Medical University, Beijing, China.
Wei YuDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. yuweimd@163.com.ORCID 0000-0003-0672-2461
Debiao LiBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Capital Medical University · CNCedars-Sinai Medical Center · USSiemens Healthcare (United States) · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary high intensity plaques (CHIPs) detected using cardiovascular magnetic resonance (CMR) coronary atherosclerosis T1-weighted characterization with integrated anatomical reference (CATCH) have been shown to be positively associated with high-risk morphology observed on intracoronary optical coherence tomography (OCT). This study sought to validate whether CHIPs detected on CATCH indicate the presence of intraplaque hemorrhage (IPH) through ex vivo imaging of carotid and coronary plaque specimens, with histopathology as the standard reference.

methodsTen patients scheduled to undergo carotid endarterectomy underwent CMR with the conventional T1-weighted (T1w) sequence. Eleven carotid atherosclerotic plaques removed at carotid endarterectomy and six coronary artery endarterectomy specimens removed from patients undergoing coronary artery bypass grafting (CABG) were scanned ex vivo using both the conventional T1w sequence and CATCH. Both in vivo and ex vivo images were examined for the presence of IPH. The sensitivity, specificity, and Cohen Kappa (k) value of each scan were calculated using matched histological sections as the reference. k value between each scan in the discrimination of IPH was also computed.

resultsA total of 236 in vivo locations, 328 ex vivo and matching histology locations were included for the analysis. Sensitivity, specificity, and k value were 76.7%, 95.3%, and 0.75 for in vivo T1w imaging, 77.2%, 97.4%, and 0.78 for ex vivo T1w imaging, and 95.0%, 92.1%, and 0.84 for ex vivo CATCH, respectively. Moderate agreement was reached between in vivo T1w imaging, ex vivo T1w imaging, and ex vivo CATCH for the detection of IPH: between in vivo T1w imaging and ex vivo CATCH (k = 0.68), between ex vivo T1w imaging and ex vivo CATCH (k = 0.74), between in vivo T1w imaging and ex vivo T1w imaging (k = 0.83). None of the coronary artery plaque locations showed IPH.

conclusionThis study demonstrated that carotid CHIPs detected by CATCH can be used to assess for IPH, a high-risk plaque feature.

Indexed as

Magnetic Resonance ImagingPlaque, AtheroscleroticAgedBiopsyCarotid ArteriesCarotid Artery DiseasesCoronary Artery DiseaseCoronary VesselsEndarterectomy, CarotidFemaleHemorrhageHumansMaleMiddle AgedPredictive Value of TestsPreliminary DataCATCHCoronary high intensity plaques (CHIPs)Intraplaque hemorrhageT1w imaging

Identifiers

PMID29695254
PMCPMC5918570
OpenAlexW2805989878

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.