ArticleBMC genomics2018
Identification of genomic regions and candidate genes for chicken meat ultimate pH by combined detection of selection signatures and QTL.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Genome-wide association study of growth, carcass, and meat quality traits in Liangshan Yanying chickens.Poultry science · 2026Article
- Identification of age-related biomarkers for meat quality in Kangle chickens using multi-omics.Food chemistry. Molecular sciences · 2026Article
- Effects of Modified Corn Straw Dietary Fiber on Growth Performance, Nutrient Metabolism, Serum Biochemistry, Antioxidant Capacity, and Hepatic Lipid Deposition in Broiler.Animals : an open access journal from MDPI · 2026Article
- Effects of replacing soybean meal with an equivalent amount of fermented feed on the production performance and egg and meat quality of laying hens during the late laying period.Archives animal breeding · 2025Article
- Implication of digestive functions and microbiota in the establishment of muscle glycogen differences between divergent lines for ultimate pH.Scientific reports · 2024Article
- Unraveling the Genetic Foundations of Broiler Meat Quality: Advancements in Research and Their Impact.Genes · 2024Review
- Application potential of chicken DNA chip in domestic pigeon species - Preliminary results.Saudi journal of biological sciences · 2023Article
- Article
- Chronological Expression ofAnimals : an open access journal from MDPI · 2021Article
- Estimation of Natural Selection and Allele Age from Time Series Allele Frequency Data Using a Novel Likelihood-Based Approach.Genetics · 2020Article
- Molecular Phenotyping of White Striping and Wooden Breast Myopathies in Chicken.Frontiers in physiology · 2020Article
- Inference of Selection from Genetic Time Series Using Various Parametric Approximations to the Wright-Fisher Model.G3 (Bethesda, Md.) · 2019Article
- Differential expression and co-expression gene network analyses reveal molecular mechanisms and candidate biomarkers involved in breast muscle myopathies in chicken.Scientific reports · 2019Article
- Predicting the Quality of Meat: Myth or Reality?Foods (Basel, Switzerland) · 2019Review
- Mapping QTL for white striping in relation to breast muscle yield and meat quality traits in broiler chickens.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe understanding of the biological determinism of meat ultimate pH, which is strongly related to muscle glycogen content, is a key point for the control of muscle integrity and meat quality in poultry. In the present study, we took advantage of a unique model of two broiler lines divergently selected for the ultimate pH of the pectoralis major muscle (PM-pHu) in order to decipher the genetic control of this trait. Two complementary approaches were used: detection of selection signatures generated during the first five generations and genome-wide association study for PM-pHu and Sartorius muscle pHu (SART-pHu) at the sixth generation of selection.
resultsSixty-three genomic regions showed significant signatures of positive selection. Out of the 10 most significant regions (detected by HapFLK or FLK method with a p-value below 1e-6), 4 were detected as soon as the first generation (G1) and were recovered at each of the four following ones (G2-G5). Another four corresponded to a later onset of selection as they were detected only at G5. In total, 33 SNPs, located in 24 QTL regions, were significantly associated with PM-pHu. For SART-pHu, we detected 18 SNPs located in 10 different regions. These results confirmed a polygenic determinism for these traits and highlighted two major QTL: one for PM-pHu on GGA1 (with a Bayes Factor (BF) of 300) and one for SART-pHu on GGA4 (with a BF of 257). Although selection signatures were enriched in QTL for PM-pHu, several QTL with strong effect haven't yet responded to selection, suggesting that the divergence between lines might be further increased.
conclusionsA few regions of major interest with significant selection signatures and/or strong association with PM-pHu or SART-pHu were evidenced for the first time in chicken. Their gene content suggests several candidates associated with diseases of glycogen storage in humans. The impact of these candidate genes on meat quality and muscle integrity should be further investigated in chicken.
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