Evidence map›Paper›PMID 29695168›Full record

ReviewCephalalgia : an international journal of headache2019

Cortical spreading depression as a site of origin for migraine: Role of CGRP.

Liesl N Close, Sajedeh Eftekhari, Minyan Wang, Andrew C Charles, Andrew F Russo

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cephalalgia : an international journal of headache, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 4 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Prophylactic Management of Vestibular Migraine: A Systematic Review.Annals of clinical and translational neurology · 2025
    Pooled it
  3. Mechanosensitive receptors in migraine: a systematic review.The journal of headache and pain · 2024
    Pooled it
  4. Pooled it
  5. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Trial
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Sirtuins Contribute to the Migraine-Stroke Connection.International journal of molecular sciences · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Revisiting Migraine Pathophysiology: from Neurons To Immune Cells Through Lens of Immune Regulatory Pathways.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Liesl N Close1 Department of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Sajedeh Eftekhari2 UCLA Goldberg Migraine Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Minyan Wang3 Centre for Neuroscience, Department of Biological Sciences, Xi'an Jiaotong-Liverpool University (XJTLU), SIP, Suzhou, China.ORCID 0000-0002-7955-1627
Andrew C Charles2 UCLA Goldberg Migraine Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Andrew F Russo4 Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.
University of California, Los Angeles · USUniversity of Iowa · USXi’an Jiaotong-Liverpool University · CN

Funding

Perivascular mechanisms of CGRP-induced migraine symptomsR01NS075599 · NINDS · UNIVERSITY OF IOWA · PI RUSSO, ANDREW F · 2011 to 2023
$5.0M
Photosensitivity as a preclinical assessment for treatment of post-traumatic headacheI01RX002101 · VA · IOWA CITY VA MEDICAL CENTER · PI PIEPER, ANDREW A, RUSSO, ANDREW F · 2016 to 2020
–
NINDS NIH HHS R01 NS075599RRD VA I01 RX002101
6 · The paper itself

Abstract

premiseMigraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood. PROBLEM: One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Despite the importance of both cortical spreading depression and calcitonin gene-related peptide in migraine, the relationship between these two players has been relatively unexplored. However, recent data suggest several potential vascular and neural connections between calcitonin gene-related peptide and cortical spreading depression.

conclusionThis review will outline calcitonin gene-related peptide-cortical spreading depression connections and propose a model in which cortical spreading depression and calcitonin gene-related peptide act at the intersection of the vasculature and cortical neurons, and thus contribute to migraine pathophysiology.

Indexed as

AnimalsCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsCortical Spreading DepressionHumansMigraine DisordersReceptors, Calcitonin Gene-Related PeptideTrigeminal NerveVasodilationCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsReceptors, Calcitonin Gene-Related Peptidecortical spreading depressionNeurovasculaturetrigeminal nervevasodilation

Identifiers

PMID29695168
PMCPMC7007998
OpenAlexW2799966795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.