Evidence map›Paper›PMID 29694964›Full record

ArticleDementia and geriatric cognitive disorders2018

Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer's Disease Neuroimaging Initiative (ADNI).

Julius S Ngwa, Thomas V Fungwe, Oyonumo Ntekim, Joanne S Allard, Sheree M Johnson, Chimene Castor, Lennox Graham, Sheeba Nadarajah, Richard F Gillum, Thomas O Obisesan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julius S NgwaDivision of Cardiovascular Medicine, Department of Medicine, Howard University College of Medicine, Washington, District of Columbia, USA.
Thomas V FungweDepartment of Nutritional Sciences, School of Nursing and Allied Health Sciences, and Department of Medicine, Howard University College of Medicine, Washington, District of Columbia, USA.
Oyonumo NtekimDepartment of Nutritional Sciences, School of Nursing and Allied Health Sciences, and Department of Medicine, Howard University College of Medicine, Washington, District of Columbia, USA.
Joanne S AllardDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, District of Columbia, USA.
Sheree M JohnsonDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, District of Columbia, USA.
Chimene CastorDepartment of Nutritional Sciences, School of Nursing and Allied Health Sciences, and Department of Medicine, Howard University College of Medicine, Washington, District of Columbia, USA.
Lennox GrahamDepartment of Health Education, School of Nursing and Allied Health Sciences, and Department of Medicine, Howard University College of Medicine, Washington, District of Columbia, USA.
Sheeba NadarajahDivision of Nursing, School of Nursing and Allied Health Sciences, and Department of Medicine, Howard University College of Medicine, Washington, District of Columbia, USA.
Richard F GillumDivision of Geriatrics, Department of Medicine and Clinical/Translational Science Program, Howard University College of Medicine/Hospital, Washington, District of Columbia, USA.
Thomas O ObisesanDivision of Geriatrics, Department of Medicine and Clinical/Translational Science Program, Howard University College of Medicine/Hospital, Washington, District of Columbia, USA.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1TR000101 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2015
$19.3M
Genes, Exercise, Neurocognitive and Neurodegeneration: Community-Based ApproachR01AG045058 · NIA · HOWARD UNIVERSITY · PI OBISESAN, THOMAS O · 2014 to 2018
$2.9M
Effects of Standardized Aerobic Exercise-Training on Neurocognitive and NeurodegeR01AG031517 · NIA · HOWARD UNIVERSITY · PI OBISESAN, THOMAS O · 2009 to 2010
$2.0M
Eye and Vision Genomics Training ProgramT32EY022303 · NEI · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2013 to 2017
$799k
NCATS NIH HHS UL1 TR000101NCATS NIH HHS UL1 TR001409NEI NIH HHS T32 EY022303NIA NIH HHS R01 AG031517NIA NIH HHS R01 AG045058NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

backgroundIt is increasingly evident that high blood pressure can promote reduction in global and regional brain volumes. While these effects may preferentially affect the hippocampus, reports are inconsistent.

methodsUsing data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we examined the relationships of hippocampal volume to pulse pressure (PPR) and systolic (SBP) and diastolic (DBP) blood pressure according to apolipoprotein (APOE) ɛ4 positivity and cognitive status. The ADNI data included 1,308 participants: Alzheimer disease (AD = 237), late mild cognitive impairment (LMCI = 454), early mild cognitive impairment (EMCI = 254), and cognitively normal (CN = 365), with up to 24 months of follow-up.

resultsHigher quartiles of PPR were significantly associated with lower hippocampal volumes (Q1 vs. Q4, p = 0.034) in the CN and AD groups, but with increasing hippocampal volume (Q1, p = 0.008; Q2, p = 0.020; Q3, p = 0.017; Q4 = reference) in the MCI groups. In adjusted stratified analyses among non-APOE ɛ4 carriers, the effects in the CN (Q1 vs. Q4, p = 0.006) and EMCI groups (Q1, p = 0.002; Q2, p = 0.013; Q3, p = 0.002; Q4 = reference) remained statistically significant. Also, higher DBP was significantly associated with higher hippocampal volume (p = 0.002) while higher SBP was significantly associated with decreasing hippocampal volume in the EMCI group (p = 0.015).

conclusionChanges in PPR, SBP, and DBP differentially influenced hippocampal volumes depending on the cognitive and APOE genotypic categories.

Indexed as

Blood PressureCognitionHeart RateAgedAged, 80 and overAlzheimer DiseaseApolipoproteins ECognitive DysfunctionFemaleGenotypeHippocampusHumansMagnetic Resonance ImagingMaleNeuroimagingNeuropsychological TestsApolipoproteins EAlzheimer diseaseAPOE ε4Blood pressureHippocampal volumePulse pressure

Identifiers

PMID29694964
PMCPMC6143389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.