ArticleOphthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde2018
Treatment of Macular Degeneration with Sildenafil: Results of a Two-Year Trial.
Article in Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04356716 (Sildenafil for Treatment of Choroidal Ischemia), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sildenafil for Treatment of Choroidal Ischemia
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Pathophysiology of sildenafil-induced ocular toxicity in rats and treatment.International journal of ophthalmology · 2026Article
- Color Doppler Imaging, Endothelin-1, Corneal Biomechanics and Scleral Rigidity in Asymmetric Age-Related Macular Degeneration.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Multimodal imaging in Best Vitelliform Macular Dystrophy: Literature review and novel insights.European journal of ophthalmology · 2024Review
- Chronic sildenafil citrate use decreases retinal vascular endothelial growth factor expression in diabetic rats: a pilot study.International journal of retina and vitreous · 2023Article
- Optical Coherence Tomography-Based Choroidal Structural Analysis and Vascularity Index in Best Vitelliform Macular Dystrophy.Ophthalmology and therapy · 2022Article
- Ophthalmic artery angioplasty for age-related macular degeneration.Journal of neurointerventional surgery · 2022Article
- New focus on regulation of the rod photoreceptor phosphodiesterase.Current opinion in structural biology · 2021Review
- Visual Side Effects Linked to Sildenafil Consumption: An Update.Biomedicines · 2021Review
- Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil).American journal of ophthalmology case reports · 2021Article
- Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice.PloS one · 2021Article
- Prospective Impact of Sildenafil on Chronic cEntral Serous Chorioretinopathy: PISCES Trial.Ophthalmology. Retina · 2020Article
- Article
- Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration.Journal of ophthalmology · 2020Article
- Effects of phosphodiesterase type 5 inhibitors on choroid and ocular vasculature: a literature review.International journal of retina and vitreous · 2020Review
- Chronic Central Serous Chorioretinopathy with Pigment Epithelium Detachment Treated with Sildenafil: A Case Report.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate PDE5/6 inhibition with sildenafil to reduce choroidal ischemia and treat age-related macular degeneration.
methodsSildenafil was prescribed to treat participants with macular degenerations or macular dystrophies measured by spectral-domain optical coherence tomography, color fundus photography, enhanced depth imaging, and best-corrected visual acuity.
resultsNo change in calcified drusen was noted. Vitelliform-type soft drusen were not substantially changed. A participant with Best vitelliform macular dystrophy had a significant improvement in vision as well as in photoreceptor and ellipsoid layers.
conclusionsOur research supports sildenafil as a safe treatment for age-related and vitelliform macular degenerations. Thickened Bruch's membrane reduces the beneficial effect of perfusion increase, but all eyes appear to benefit from PDE6. Notably, maintenance or improvement in the photoreceptor layer may be the most significant result of sildenafil and is consistent with PDE6 inhibition. Thus, sil-denafil treatment of macular degeneration offers significant potential for vision retention and recovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.