Evidence map›Paper›PMID 29694927›Full record

ReviewCurrent opinion in neurobiology2018

Transcription factor mechanisms guiding motor neuron differentiation and diversification.

Clinton Cave, Shanthini Sockanathan

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  7. Article
  8. Review
  9. Article
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  12. Article
  13. The Hox GeneJournal of developmental biology · 2020
    Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Clinton CaveThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725N Wolfe Street, PCTB 1004, Baltimore, MD 21205, United States.
Shanthini SockanathanThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725N Wolfe Street, PCTB 1004, Baltimore, MD 21205, United States. Electronic address: ssockan1@jhmi.edu.
Johns Hopkins Medicine · US

Funding

Retinoids and the specification of spinal motor neuronsR01NS046336 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SOCKANATHAN, SHANTHINI · 2003 to 2017
$4.6M
Molecular Mechanisms of Motor Neuron DevelopmentR56NS046336 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SOCKANATHAN, SHANTHINI · 2007 to 2007
$409k
NINDS NIH HHS R01 NS046336NINDS NIH HHS R56 NS046336
6 · The paper itself

Abstract

The embryonic generation of motor neurons is a complex process involving progenitor patterning, fate specification, differentiation, and maturation. Throughout this progression, the differential expression of transcription factors has served as our road map for the eventual cell fate of nascent motor neurons. Recent findings from in vivo and in vitro models of motor neuron development have expanded our understanding of how transcription factors govern motor neuron identity and their individual regulatory mechanisms. With the advent of next generation sequencing approaches, researchers now have unprecedented access to the gene regulatory dynamics involved in motor neuron development and are uncovering new connections linking neurodevelopment and neurodegenerative disease.

Indexed as

AnimalsCell DifferentiationGene Expression Regulation, DevelopmentalMotor NeuronsTranscription FactorsTranscription Factors

Identifiers

PMID29694927
PMCPMC6196124
OpenAlexW2806629983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.