Evidence map›Paper›PMID 29694881›Full record

ArticleCell reports2018

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca

Neeharika Nemani, Edmund Carvalho, Dhanendra Tomar, Zhiwei Dong, Andrea Ketschek, Sarah L Breves, Fabián Jaña, Alison M Worth, Julie Heffler, Palaniappan Palaniappan and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 113 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 10 institutions in 2 countries.

Neeharika NemaniDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Edmund CarvalhoDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Dhanendra TomarDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Zhiwei DongDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Andrea KetschekDepartment of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Sarah L BrevesDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Fabián JañaDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Alison M WorthDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Julie HefflerDepartment of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Palaniappan PalaniappanDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Aparna TripathiDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Ramasamy SubbiahDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Massimo F RiitanoDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Ajay SeelamDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Thomas ManfredDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Kie ItohDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shuxia MengDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
William J CraigenDepartment of Molecular and Human Genetics, The Mitochondrial Diagnostic Laboratory, Baylor College of Medicine, Houston, TX 77030, USA.
Sudarsan RajanDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Santhanam ShanmughapriyaDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Jeffrey CaplanDepartment of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA.
Benjamin L ProsserDepartment of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Donald L GillDepartment of Cellular and Molecular Physiology, Penn State Hershey College of Medicine, Hershey, PA 17033, USA.
Peter B StathopulosDepartment of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada.
Gianluca GalloDepartment of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
David C ChanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Prashant MishraChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Muniswamy MadeshDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address: madeshm@temple.edu.
Temple University · USCalifornia Institute of Technology · USUniversity of Pennsylvania · USBaylor College of Medicine · USBiotechnology Institute · USChildren's Medical Center · USJohns Hopkins Medicine · USJohns Hopkins University · USPenn State Milton S. Hershey Medical Center · USWestern University · CA

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Jeffrey L Caplan · 2012 to 2026
$67.2M
Coordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3M
Spectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3M
Mechanism and function of the fission of axonal mitochondriaR01NS095471 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI GALLO, GIANLUCA · 2016 to 2020
$1.7M
Calcium Signaling Roles of STIM1 and STIM2 in Smooth MuscleR01GM109279 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2014 to 2017
$1.6M
Inhibition of MCUR1-MCU mediated mitochondrial Ca2+ uptake prevents I/R injuryR01HL119306 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2014 to 2017
$1.6M
Control of Calcium Entry Signals in B CellsR01GM120783 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2016 to 2018
$1.3M
Multiphoton Confocal Microscopy for Biomedical ResearchS10RR027327 · NCRR · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2010 to 2010
$500k
Molecular link between MCU and Mrs2p channels for mitochondrial ion homeostasis and energy metabolismK99HL138268 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI SANTHANAM, SHANMUGHAPRIYA · 2017 to 2018
$201k
American Heart Association-American Stroke Association 17POST33660251NCRR NIH HHS S10 RR027327NHLBI NIH HHS K99 HL138268NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL119306NIGMS NIH HHS P20 GM103446NIGMS NIH HHS R01 GM109279NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM120783
6 · The paper itself

Abstract

Mitochondria shape cytosolic calcium ([Ca

Indexed as

Mitochondrial DynamicsStress, PhysiologicalAnimalsCalciumHeLa CellsHumansMiceMice, Mutant StrainsMitochondriaReceptors, G-Protein-Coupledrho GTP-Binding ProteinsCalciumMiro-1 protein, mouseReceptors, G-Protein-Coupledrho GTP-Binding ProteinsautophagycalciumEF handMCUMiroMiSTmitochondrial dynamicsmitochondrial shapemitophagyPTP

Identifiers

PMID29694881
PMCPMC5973819
OpenAlexW2803005522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.