Evidence map›Paper›PMID 29694240›Full record

ArticleAmerican journal of respiratory and critical care medicine2018

Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy.

Malancha Karmakar, Maria Globan, Janet A M Fyfe, Timothy P Stinear, Paul D R Johnson, Natasha E Holmes, Justin T Denholm, David B Ascher

Abstract readCase ReportsLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  3. Engineering G protein-coupled receptors for stabilization.Protein science : a publication of the Protein Society · 2024
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  5. AI-Driven Enhancements in Drug Screening and Optimization.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. Article
  7. Using Graph-Based Signatures to Guide Rational Antibody Engineering.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  8. Article
  9. Drug Degradation Caused byAntimicrobial agents and chemotherapy · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Genome analyses of 174 strains ofMicrobial genomics · 2021
    Article
  15. Article
  16. Distinguishing between PTEN clinical phenotypes through mutation analysis.Computational and structural biotechnology journal · 2021
    Article
  17. Structural and Genomic Insights Into Pyrazinamide Resistance inFrontiers in molecular biosciences · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Malancha Karmakar1 University of Melbourne Melbourne, Victoria, Australia and.
Maria Globan1 University of Melbourne Melbourne, Victoria, Australia and.
Janet A M Fyfe1 University of Melbourne Melbourne, Victoria, Australia and.
Timothy P Stinear1 University of Melbourne Melbourne, Victoria, Australia and.
Paul D R Johnson1 University of Melbourne Melbourne, Victoria, Australia and.
Natasha E Holmes1 University of Melbourne Melbourne, Victoria, Australia and.
Justin T Denholm1 University of Melbourne Melbourne, Victoria, Australia and.
David B Ascher1 University of Melbourne Melbourne, Victoria, Australia and.ORCID 0000-0003-2948-2413

Funding

Medical Research Council MR/M026302/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAmidohydrolasesAntitubercular AgentsFemaleHumansMutationPyrazinamideSequence Analysis, DNATuberculosis, Multidrug-ResistantAmidohydrolasesAntitubercular AgentsPncA protein, Mycobacterium tuberculosisPyrazinamide

Identifiers

PMID29694240
PMCPMC6118032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.