Evidence map›Paper›PMID 29694012›Full record

ArticleACS nano2018

Defects and Chirality in the Nanoparticle-Directed Assembly of Spherocylindrical Shells of Virus Coat Proteins.

Cheng Zeng, Guillermo Rodriguez Lázaro, Irina B Tsvetkova, Michael F Hagan, Bogdan Dragnea

Abstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Pleomorphism in Wild-Type and Engineered PP7 Virus-Like Particles.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Fluorescent nanodiamonds encapsulated byJournal of materials chemistry. B · 2021
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cheng ZengDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Guillermo Rodriguez LázaroDepartment of Physics , Brandeis University , Waltham , Massachusetts 02453 , United States.
Irina B TsvetkovaDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Michael F HaganDepartment of Physics , Brandeis University , Waltham , Massachusetts 02453 , United States.
Bogdan DragneaDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.ORCID 0000-0003-0611-2006

Funding

Computational modeling of viral capsid and bacterial microcompartment assemblyR01GM108021 · NIGMS · BRANDEIS UNIVERSITY · PI HAGAN, MICHAEL F · 2013 to 2021
$2.7M
NIGMS NIH HHS R01 GM108021
6 · The paper itself

Abstract

Virus coat proteins of small isometric plant viruses readily assemble into symmetric, icosahedral cages encapsulating noncognate cargo, provided the cargo meets a minimal set of chemical and physical requirements. While this capability has been intensely explored for certain virus-enabled nanotechnologies, additional applications require lower symmetry than that of an icosahedron. Here, we show that the coat proteins of an icosahedral virus can efficiently assemble around metal nanorods into spherocylindrical closed shells with hexagonally close-packed bodies and icosahedral caps. Comparison of chiral angles and packing defects observed by in situ atomic force microscopy with those obtained from molecular dynamics models offers insight into the mechanism of growth, and the influence of stresses associated with intrinsic curvature and assembly pathways.

Indexed as

BromovirusCapsid ProteinsGoldMetal NanoparticlesMicroscopy, Atomic ForceMicroscopy, Electron, TransmissionModels, MolecularCapsid ProteinsGoldchiralitydefectsnanoparticle-directed assemblypackingvirus-like particles

Identifiers

PMID29694012
PMCPMC6202266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.