ArticleThe New phytologist2018
A fungal avirulence factor encoded in a highly plastic genomic region triggers partial resistance to septoria tritici blotch.
Article in The New phytologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed.
- Genome-host association mapping reveals wheat pathogen genes involved in host specialization.Nature plants · 2026Article
- EffectorFisher: association of disease phenotype with pangenomic protein-isoform profiles for improved prediction of fungal pathogenicity effectors.Scientific reports · 2026Article
- Article
- Zymoseptoria tritici stealth infection is facilitated by stage-specific downregulation of a β-glucanase.The New phytologist · 2025Article
- Integrating host-pathogen interaction genomics to boost wheat defense against septoria tritici blotch.BMC genomics · 2025Article
- Transposon-Associated Small RNAs Involved in Plant Defense in Poplar.Plants (Basel, Switzerland) · 2025Article
- Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici.PLoS pathogens · 2025Article
- Genome-wide association study reveals major loci for resistance to septoria tritici blotch in a Tunisian durum wheat collection.PloS one · 2025Article
- The genetic architecture of resistance to septoria tritici blotch in French wheat cultivars.BMC plant biology · 2024Article
- An array of Zymoseptoria tritici effectors suppress plant immune responses.Molecular plant pathology · 2024Article
- Stomatal penetration: the cornerstone of plant resistance to the fungal pathogen Zymoseptoria tritici.BMC plant biology · 2024Article
- Article
- Quantitative pathogenicity and host adaptation in a fungal plant pathogen revealed by whole-genome sequencing.Nature communications · 2024Article
- Article
- Genome-wide expression QTL mapping reveals the highly dynamic regulatory landscape of a major wheat pathogen.BMC biology · 2023Article
- Virulent strains of Zymoseptoria tritici suppress the host immune response and facilitate the success of avirulent strains in mixed infections.PLoS pathogens · 2023Article
- Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen.PLoS pathogens · 2023Article
- Sas3-mediated histone acetylation regulates effector gene activation in a fungal plant pathogen.mBio · 2023Article
- A secreted protease-like protein in Zymoseptoria tritici is responsible for avirulence on Stb9 resistance gene in wheat.PLoS pathogens · 2023Article
- A thousand-genome panel retraces the global spread and adaptation of a major fungal crop pathogen.Nature communications · 2023Article
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7 authors.
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Abstract
Cultivar-strain specificity in the wheat-Zymoseptoria tritici pathosystem determines the infection outcome and is controlled by resistance genes on the host side, many of which have been identified. On the pathogen side, however, the molecular determinants of specificity remain largely unknown. We used genetic mapping, targeted gene disruption and allele swapping to characterise the recognition of the new avirulence factor Avr3D1. We then combined population genetic and comparative genomic analyses to characterise the evolutionary trajectory of Avr3D1. Avr3D1 is specifically recognised by wheat cultivars harbouring the Stb7 resistance gene, triggering a strong defence response without preventing pathogen infection and reproduction. Avr3D1 resides in a cluster of putative effector genes located in a genome region populated by independent transposable element insertions. The gene was present in all 132 investigated strains and is highly polymorphic, with 30 different protein variants identified. We demonstrated that specific amino acid substitutions in Avr3D1 led to evasion of recognition. These results demonstrate that quantitative resistance and gene-for-gene interactions are not mutually exclusive. Localising avirulence genes in highly plastic genomic regions probably facilitates accelerated evolution that enables escape from recognition by resistance proteins.
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