Evidence map›Paper›PMID 29693595›Full record

ReviewInternational journal of molecular sciences2018

The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?

Laura de Ramon, Jordi Guiteras, Roser Guiteras, Josep M Cruzado, Josep M Grinyó, Juan Torras

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury.International journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laura de RamonExperimental and Translational Laboratory of Nephrology, Clinic Sciences Department, Universitat de Barcelona, Institut d'investigació biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08907 Barcelona, Spain. lderamon@idibell.cat.
Jordi GuiterasExperimental and Translational Laboratory of Nephrology, Clinic Sciences Department, Universitat de Barcelona, Institut d'investigació biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08907 Barcelona, Spain. jguiteras@idibell.cat.
Roser GuiterasExperimental and Translational Laboratory of Nephrology, Clinic Sciences Department, Universitat de Barcelona, Institut d'investigació biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08907 Barcelona, Spain. rguiteras@idibell.cat.
Josep M CruzadoExperimental and Translational Laboratory of Nephrology, Clinic Sciences Department, Universitat de Barcelona, Institut d'investigació biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08907 Barcelona, Spain. jmcruzado@bellvitgehospital.cat.
Josep M GrinyóExperimental and Translational Laboratory of Nephrology, Clinic Sciences Department, Universitat de Barcelona, Institut d'investigació biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08907 Barcelona, Spain. jgrinyo@ub.edu.
Juan TorrasExperimental and Translational Laboratory of Nephrology, Clinic Sciences Department, Universitat de Barcelona, Institut d'investigació biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08907 Barcelona, Spain. jtorras@bellvitgehospital.cat.ORCID 0000-0002-1135-7588
Bellvitge University Hospital · ESInstitut d'Investigació Biomédica de Bellvitge · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Costimulatory molecules have been identified as crucial regulators in the inflammatory response in various immunologic disease models. These molecules are classified into four different families depending on their structure. Here, we will focus on various ischemia studies that use costimulatory molecules as a target to reduce the inherent inflammatory status. Furthermore, we will discuss the relevant role of T regulatory cells in these inflammatory mechanisms and the costimulatory pathways in which they are involved.

Indexed as

AnimalsCostimulatory and Inhibitory T-Cell ReceptorsCytokinesHumansReperfusion InjurySignal TransductionT-Lymphocytes, RegulatoryCostimulatory and Inhibitory T-Cell ReceptorsCytokinescostimulatory moleculesischemiaregulatory T cells

Identifiers

PMID29693595
PMCPMC5983665
OpenAlexW2801296706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.