Evidence map›Paper›PMID 29693180›Full record

ArticleMolecular medicine reports2018

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7.

Chien-Ying Lee, Chi-Yu Yang, Ching-Che Lin, Min-Chien Yu, Shuenn-Jyi Sheu, Yu-Hsiang Kuan

Open access · bronzeAbstract read
In one paragraph

Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Chien-Ying LeeDepartment of Pharmacology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C.
Chi-Yu YangDivision of Animal Medicine, Animal Technology Laboratories, Agricultural Technology Research Institute, Miaoli 35053, Taiwan, R.O.C.
Ching-Che LinBrion Research Institute of Taiwan, New Taipei 23143, Taiwan, R.O.C.
Min-Chien YuDepartment of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan, R.O.C.
Shuenn-Jyi SheuBrion Research Institute of Taiwan, New Taipei 23143, Taiwan, R.O.C.
Yu-Hsiang KuanDepartment of Pharmacology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C.
Chung Shan Medical University · TWTaipei Institute of Pathology · TWAgricultural Technology Research Institute · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragali radix, Radix Angelicae sinensis, Ligustri fructus, Rehmannia glutinosa and Eclipta prostrata (Linn). Susbsequent to oral administration of BT at 0.6 g/kg/day to wax/rosin‑induced alopecia in C57BL/6 mice, BT significantly induced hair growth at day 8 compared with control treatment (P<0.05). The expression levels of epidermal growth factor (EGF), and fibroblast growth factor (FGF)‑7 were increased compared with control animals on day 8. In contrast, levels of FGF‑5 of the BT group were reduced compared with the control on day 12. There were no effects on the expression of insulin‑like growth factor 1. The results demonstrated that the mechanism of BT improving alopecia is potentially associated with modulation of EGF and FGF‑7 levels. Taken together, it is suggested that BT may have a potential effect of the promotion of hair growth.

Indexed as

Dietary SupplementsGene ExpressionAnimalsEpidermal Growth FactorFemaleFibroblast Growth Factor 5Fibroblast Growth Factor 7HairImmunohistochemistryInsulin-Like Growth Factor IMiceEpidermal Growth FactorFGF7 protein, humanFibroblast Growth Factor 5Fibroblast Growth Factor 7Insulin-Like Growth Factor I

Identifiers

PMID29693180
PMCPMC5983978
OpenAlexW2800814881

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.