Evidence map›Paper›PMID 29692884›Full record

ArticleJournal of surgical case reports2018

Use of amniotic membrane in the treatment of patients with BRONJ: two case reports.

Mirko Ragazzo, Diletta Trojan, Lisa Spagnol, Adolfo Paolin, Luca Guarda Nardini

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of surgical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Human amniotic membrane application in oral surgery-AnFrontiers in bioengineering and biotechnology · 2022
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mirko RagazzoMaxillofacial Surgery Multispecialty Department, Ospedale Ca' Foncello [Ca' Foncello Hospital], Piazzale Ospedale 1, 31100 Treviso, Italy.
Diletta TrojanFondazione Banca dei Tessuti di Treviso onlus [Treviso Tissue Bank Foundation non-profit organisation], Piazzale Ospedale 1, 31100 Treviso, Italy.
Lisa SpagnolFondazione Banca dei Tessuti di Treviso onlus [Treviso Tissue Bank Foundation non-profit organisation], Piazzale Ospedale 1, 31100 Treviso, Italy.
Adolfo PaolinFondazione Banca dei Tessuti di Treviso onlus [Treviso Tissue Bank Foundation non-profit organisation], Piazzale Ospedale 1, 31100 Treviso, Italy.
Luca Guarda NardiniMaxillofacial Surgery Multispecialty Department, Ospedale Ca' Foncello [Ca' Foncello Hospital], Piazzale Ospedale 1, 31100 Treviso, Italy.
Veneto Eye Bank Foundation · ITCa' Foncello Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of bisphosphonates has led to a new disease, bisphosphonate-related osteonecrosis of the jaw (BRONJ). There is currently no effective treatment for this disease; the surgical approach is controversial. The widespread use of human amniotic membrane (HAM) in surgery and the results obtained have highlighted its many potential properties, including antimicrobial, anti-inflammatory, antifibrotic and antiapoptotic, as well as its capacity for encouraging epithelialisation and cell differentiation. These properties are believed to encourage the recovery of patients with BRONJ, facilitating the wound healing process after surgical debridement of the bone. We report our experience with the use of HAM: two patients treated with patches of HAM. The follow-up to date, which includes x-rays and clinical assessments, demonstrates good levels of epithelialisation and absence of infections and pain. To conclude, the use of HAM in patients with BRONJ seems to be a promising therapeutic alternative to current conventional treatments.

Identifiers

PMID29692884
PMCPMC5909437
OpenAlexW2802896460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.