ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2018
The course of asthma during pregnancy in a recent, multicase-control study on respiratory health.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Maternal asthma activity and offspring asthma: a linked-data population study in Australia and Sweden.BMJ open respiratory research · 2026Article
- Engagement and outcomes of virtual antenatal asthma care: a randomised controlled tele-trial.ERJ open research · 2025Article
- Applications of Forced Oscillatory Technique in Obstructive and Restrictive Pulmonary Diseases: A Concise State of the Art.Journal of clinical medicine · 2025Review
- Infant respiratory outcomes following asthma management and exacerbations in pregnancy.ERJ open research · 2025Article
- Small airway disease (SAD) in asthma in pregnancy evaluated by impulse oscillometry: A cross-sectional study.Lung India : official organ of Indian Chest Society · 2025Article
- The treatable traits of asthma in pregnancy: a clinical audit.ERJ open research · 2024Article
- Neurodevelopmental Outcomes Among Offspring Exposed to Corticosteroid and B2-Adrenergic Agonists In Utero.JAMA network open · 2023Article
- Does Asthma Disrupt Psychological Wellbeing in Pregnancy?Journal of clinical medicine · 2023Article
- Review
- Determining the Clinical Course of Asthma in Pregnancy.The journal of allergy and clinical immunology. In practice · 2022Article
- Article
- Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety.Canadian respiratory journal · 2020Review
- The role of Th17 cells in the pathophysiology of pregnancy and perinatal mood and anxiety disorders.Brain, behavior, and immunity · 2019Review
- GEMA 5.3. Spanish Guideline on the Management of Asthma.Open respiratory archivesArticle
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the years it has been widely stated that approximately one-third of asthmatic women experience worsening of the disease during pregnancy. However, the literature has not been reviewed systematically and the meta-analytic reviews include old studies. This study aimed to examine whether the prevalence of worsening asthma during pregnancy is still consistent with prior estimate or it has been reduced.
methodsA detailed Clinical Questionnaire on respiratory symptoms, medical history, medication, use of services, occupation, social status, home environment and lifestyle was administered to random samples of the Italian population in the frame of the Gene Environment Interactions in Respiratory Diseases (GEIRD) study. Only clinical data belong to 2.606 subjects that completed the clinical stage of the GEIRD study, were used for the present study.
resultsOut of 1.351 women, 284 self-reported asthma and 92 of them had at least one pregnancy. When we considered the asthma course during pregnancy, we found that 16 women worsened, 31 remained unchanged, 25 improved. Seven women had not the same course in the different pregnancies and 13 did not know. The starting age of ICS use almost overlaps with that of asthma onset in women with worsening asthma during pregnancy (19 years ± 1.4), unlike the other women who started to use ICS much later (30.3 years ± 12). In addition, the worsening of asthma was more frequent in women with an older age of onset of asthma (18 years ± 9 vs 13 years ± 10). Among women who completed the ACT during the clinical interview, the 50% of women who experienced worsening asthma during pregnancy (6/12) had an ACT score below 20.
conclusionAsthma was observed to worsen during pregnancy in a percentage much lower to that generally reported in all the previous studies. There is still room in clinical practice to further reduce worsening of asthma during pregnancy by improving asthma control, with a more structured approach to asthma education and management prepregnancy.
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