ArticleFrontiers in psychiatry2018
Bupropion Shows Different Effects on Brain Functional Connectivity in Patients With Internet-Based Gambling Disorder and Internet Gaming Disorder.
Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Treatments of internet gaming disorder: a systematic review of the evidence.Expert review of neurotherapeutics · 2020Pooled it
- Predicting IGD treatment outcomes across interventions using a whole-brain functional connectome biomarker.Dialogues in clinical neuroscience · 2027Trial
- Pharmacotherapy for online behavioral addictions: a systematic review.Future science OA · 2026Review
- Abnormal effective connectivity of default mode network subsystems affects depressive symptoms and sleep disturbances in adolescents with internet gaming disorder.BMC psychiatry · 2026Article
- Off-Label Medications and Non-Invasive Brain Stimulation (NIBS) in the Treatment of Internet Gaming Disorder: A Systematic Review and Meta-Analysis.Addictive behaviors reports · 2026Review
- Forms of interventions for problematic usage of the internet: A scoping review.Journal of behavioral addictions · 2025Article
- Functional connectivity changes in the brain of adolescents with internet addiction: A systematic literature review of imaging studies.PLOS mental health · 2024Article
- Resting-state EEG microstate analysis of internet gaming disorder and alcohol use disorder.Dialogues in clinical neuroscience · 2024Article
- Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.Dialogues in clinical neuroscience · 2023Review
- Neuroimaging correlates of internet gaming disorder: Can we achieve the promise of translating understandings of brain functioning into clinical advances?The Canadian journal of addiction · 2023Article
- A Systematic Review of Pharmacological Treatments for Internet Gaming Disorder.Psychiatry investigation · 2023Article
- The concept of recovery in gaming disorder: A scoping review.Journal of behavioral addictions · 2023Article
- Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions.Nutrients · 2023Review
- Pharmacological interventions for Problematic Usage of the Internet (PUI): A narrative review of current progress and future directions.Current opinion in behavioral sciences · 2022Article
- Sexual Differences in Internet Gaming Disorder (IGD): From Psychological Features to Neuroanatomical Networks.Journal of clinical medicine · 2022Review
- A Literature Review on the Efficacy and Related Neural Effects of Pharmacological and Psychosocial Treatments in Individuals With Internet Gaming Disorder.Psychiatry investigation · 2021Article
- Burden and Help-Seeking Behaviors Linked to Problem Gambling and Gaming: Observational Quantitative and Qualitative Analysis.JMIR mental health · 2021Article
- Managing Problematic Usage of the Internet and Related Disorders in an Era of Diagnostic Transition: An Updated Review.Clinical practice and epidemiology in mental health : CP & EMH · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInternet gaming disorder (IGD) and gambling disorder (GD) share similar clinical characteristics but show different brain functional connectivity patterns. Bupropion is known to be effective for the treatment of patients with IGD and GD. We hypothesized that bupropion may be effective for the treatment of Internet-based gambling disorder (ibGD) and IGD and that the connections between the default mode network (DMN) and cognitive control network (CCN) would be different between ibGD and IGD patients after 12 weeks of bupropion treatment.
methods16 patients with IGD, 15 patients with ibGD, and 15 healthy subjects were recruited in this study. At baseline and after 12 weeks of bupropion treatment, the clinical symptoms of patients with IGD or ibGD were assessed, and brain activity was evaluated using resting state functional magnetic resonance imaging.
resultsAfter the 12-week bupropion treatment, clinical symptoms, including the severity of IGD or GD, depressive symptoms, attention, and impulsivity improved in both groups. In the IGD group, the functional connectivity (FC) within the posterior DMN as well as the FC between the DMN and the CCN decreased following treatment. Moreover, the FC within the DMN in the IGD group was positively correlated with changes in Young Internet Addiction Scale scores after the bupropion treatment period. In the ibGD group, the FC within the posterior DMN decreased while the FC within the CCN increased after the bupropion treatment period. Moreover, the FC within the CCN in the ibGD group was significantly greater than that in the IGD group.
conclusionBupropion was effective in improving clinical symptoms in patients with IGD and ibGD. However, there were differences in the pharmacodynamics between the two groups. After 12 weeks of bupropion treatment, the FC within the DMN as well as between the DMN and CCN decreased in patients with IGD, whereas the FC within the CCN increased in patients with ibGD.
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