ArticleFrontiers in aging neuroscience2018
Pupillary Response to Cognitive Demand in Parkinson's Disease: A Pilot Study.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson's disease.Cognitive neurodynamics · 2026Article
- A Comparison of Machine Learning Models for Classification of Parkinson's Disease During a Working Memory and Sustained Attention Task.Brain sciences · 2026Article
- Clinical Validation of Pupil Response During Walking in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Predicting Cognition and Affective Changes in Newly Diagnosed Parkinson's Disease Through Longitudinal Data-Driven Clustering.Journal of geriatric psychiatry and neurology · 2026Article
- Can the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson's Disease? A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Associations between cognitive screening performance and motor symptoms in Parkinson's disease:a systematic review and meta-analysis.Dementia & neuropsychologia · 2024Review
- Cognitive workload during verbal abstract reasoning in Parkinson's disease: a pilot study.The International journal of neuroscience · 2021Article
- Reliability and Validity of Pupillary Response During Dual-Task Balance in Parkinson Disease.Archives of physical medicine and rehabilitation · 2021Article
- Pupillary Response to Postural Demand in Parkinson's Disease.Frontiers in bioengineering and biotechnology · 2021Article
- Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults.Brain sciences · 2020Article
- Pilot Feasibility Study Examining Pupillary Response During Driving Simulation as a Measure of Cognitive Load in Breast Cancer Survivors.Oncology nursing forum · 2020Article
- Changes in Prefrontal Cortical Activity During Walking and Cognitive Functions Among Patients With Parkinson's Disease.Frontiers in neurology · 2020Article
- What's That (Blue) Spot on my MRI? Multimodal Neuroimaging of the Locus Coeruleus in Neurodegenerative Disease.Frontiers in neuroscience · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to examine the pupillary response to cognitive demand in a letter-number sequencing (LNS) task between 16 non-demented individuals with PD (age, median (Q1-Q3): 68 (62-72); 10 males) and 10 control participants (age: 63 (59-67); 2 males), matched for age, education, and Montreal Cognitive Assessment (MOCA) scores. A mixed model analysis was employed to investigate cognitive workload changes as a result of incremental cognitive demand for both groups. As expected, no differences were found in cognitive scores on the LNS between groups. Cognitive workload, exemplified by greater pupil dilation, increased with incremental cognitive demand in both groups (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.