ReviewFrontiers in neuroscience2018
The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging.
Review in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.Neuroscience bulletin · 2026Article
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain.Brain structure & function · 2025Article
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Neurovascular coupling of striatal dopamine DNeuroscience applied · 2024Article
- Evaluating the pharmacodynamic effects of padsevonil in healthy volunteers using simultaneous [Neuroscience applied · 2023Article
- The Role of fMRI in Drug Development: An Update.Advances in neurobiology · 2023Article
- Characterization of Hemodynamic Alterations in Schizophrenia and Bipolar Disorder and Their Effect on Resting-State fMRI Functional Connectivity.Schizophrenia bulletin · 2022Article
- Reduced brain activity during a working memory task in middle-aged apolipoprotein E ε4 carriers with overweight/obesity.Frontiers in human neuroscience · 2022Article
- Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales.NeuroImage · 2021Article
- Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder.Journal of personalized medicine · 2021Article
- Utility of Preoperative Blood-Oxygen-Level-Dependent Functional MR Imaging in Patients with a Central Nervous System Neoplasm.Neuroimaging clinics of North America · 2021Review
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
- Hemodynamic responses are abnormal in isolated cervical dystonia.Journal of neuroscience research · 2020Article
- Questions and controversies in the study of time-varying functional connectivity in resting fMRI.Network neuroscience (Cambridge, Mass.) · 2020Review
- Utility of Preoperative Blood-Oxygen-Level-Dependent Functional MR Imaging in Patients with a Central Nervous System Neoplasm.Radiologic clinics of North America · 2019Review
- Dopamine is a double-edged sword: dopaminergic modulation enhances memory retrieval performance but impairs metacognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine.Frontiers in neuroscience · 2019Article
- Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.Frontiers in neuroinformatics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications. Pharmacological fMRI (pharma-fMRI) is a relatively new application, which is being used to elucidate the effects and mechanisms of pharmacological modulation of brain activity. Characterizing the effects of neuropharmacological agents on regional brain activity using fMRI is challenging because drugs modulate neuronal function in a wide variety of ways, including through receptor agonist, antagonist, and neurotransmitter reuptake blocker events. Here we review current knowledge on neurotransmitter-mediated blood-oxygen-level dependent (BOLD) fMRI mechanisms as well as recently updated methodologies aimed at more fully describing the effects of neuropharmacologic agents on the BOLD signal. We limit our discussion to dopaminergic signaling as a useful lens through which to analyze and interpret neurochemical-mediated changes in the hemodynamic BOLD response. We also discuss the need for future studies that use multi-modal approaches to expand the understanding and application of pharma-fMRI.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.