ReviewMediators of inflammation2018
Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics.
Review in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- LC3-associated phagocytosis in macrophage responses to Paracoccidioides spp.Memorias do Instituto Oswaldo Cruz · 2026Article
- Aspergillus fumigatus Gliotoxin Inhibits LC3-Associated Phagocytosis in Macrophages in a Calcium-Dependent Manner.Journal of immunology research · 2026Article
- ULK1 mediated autophagy in airway cells duringFrontiers in microbiology · 2026Article
- The Role of LC3-Associated Phagocytosis Inhibits the Inflammatory Response in Aspergillus fumigatus Keratitis.Investigative ophthalmology & visual science · 2024Article
- Human intestinal epithelial cells can internalize luminal fungiFrontiers in immunology · 2023Article
- Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis.Autophagy · 2023Article
- CCPG1 involved in cornealInternational journal of ophthalmology · 2022Article
- Transcriptional Remodeling Patterns in Murine Dendritic Cells Infected withJournal of fungi (Basel, Switzerland) · 2020Article
- Review
- Tryptophan as a Central Hub for Host/Microbial Symbiosis.International journal of tryptophan research : IJTR · 2020Review
- Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease.Life science alliance · 2019Article
- LC3-associated phagocytosis at a glance.Journal of cell science · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Phagocytes fight fungi using canonical and noncanonical, also called LC3-associated phagocytosis (LAP), autophagy pathways. However, the outcomes of autophagy/LAP in shaping host immune responses appear to greatly vary depending on fungal species and cell types. By allowing efficient pathogen clearance and/or degradation of inflammatory mediators, autophagy proteins play a broad role in cellular and immune homeostasis during fungal infections. Indeed, defects in autophagic machinery have been linked with aberrant host defense and inflammatory states. Thus, understanding the molecular mechanisms underlying the relationship between the different forms of autophagy may offer a way to identify drugable molecular signatures discriminating between selective recognition of cargo and host protection. In this regard, IFN-
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.