Evidence map›Paper›PMID 29692614›Full record

ArticleInternational journal of nanomedicine2018

Difunctional bacteriophage conjugated with photosensitizers for

Shuai Dong, Hongxi Shi, Xintong Zhang, Xi Chen, Donghui Cao, Chuanbin Mao, Xiang Gao, Li Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy.International journal of molecular sciences · 2021
    Review
  12. A combination therapy of Phages and Antibiotics: Two is better than one.International journal of biological sciences · 2021
    Review
  13. Article
  14. Phage Therapy in the Postantibiotic Era.Clinical microbiology reviews · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Shuai DongKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University.
Hongxi ShiKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University.
Xintong ZhangKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University.
Xi ChenKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University.
Donghui CaoFirst Hospital of Jilin University, Changchun, Jilin.
Chuanbin MaoSchool of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
Xiang GaoKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University.
Li WangKey Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University.
Northeast Normal University · CNFirst Hospital of Jilin University · CNJilin University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsIn this study, PPA was conjugated with JM-phage by EDC/NHS crosslinking. UV-Vis spectra was used to determine the optimum conjugation percentages of PPA and JM-phage complex for photodynamic inactivation. After photodynamic inactivation, the efficacy of PPA-JM-phage was assessed by performing in vitro experiments, such as MTS assay, scanning electron microscopy, measurement of dysfunctional mitochondria, ROS accumulation, S cell arrest and apoptotic pathway.

resultsA single-chain variable-fragment phage (JM) with high affinity to MP65 was screened from human single-fold single-chain variable-fragment libraries and designed as a binding target for

conclusionPPa-JM-phage may induce

Indexed as

ApoptosisBacteriophagesCandida albicansCaspasesChlorophyllFungal ProteinsHumansMembrane Potential, MitochondrialMicroscopy, Electron, ScanningMitochondriaPeptide LibraryPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesCaspasesChlorophyllFungal ProteinsPeptide Librarypheophorbide aPhotosensitizing AgentsReactive Oxygen Speciesapoptosismetacaspasephagephotodynamic therapyPPA

Identifiers

PMID29692614
PMCPMC5903486
OpenAlexW2797029583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.