Evidence map›Paper›PMID 29692599›Full record

ArticleMolecular vision2018

Structure and microanalysis of tear film ferning of camel tears, human tears, and Refresh Plus.

Masmali Am, Fagehi Ra, Ahmad H El-Naggar, Almubrad Tm, Akhtar S

Abstract read
In one paragraph

Article in Molecular vision, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Chemical composition from photos: Dried solution drops reveal a morphogenetic tree.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Single-Tear Proteomics: A Feasible Approach to Precision Medicine.International journal of molecular sciences · 2021
    Article
  5. Article
  6. Establishment of a Tear Ferning Test Protocol in the Mouse Model.Translational vision science & technology · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Masmali AmCornea Research Chair, Department of Optometry, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Fagehi RaCornea Research Chair, Department of Optometry, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Ahmad H El-NaggarSoil Sciences Department, College of Food & Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Almubrad TmCornea Research Chair, Department of Optometry, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Akhtar S

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate the tear ferning pattern and chemical elements of the tear film of camel tears compared with human tears and Refresh Plus eye lubricant. Refresh Plus was used as a control because it provides a healthy ferning pattern, due to the presence of an optimum ratio of carboxymethylcellulose (CMC) sodium and electrolytes. The main research focus is elucidating the viability of camel tear film in the dry, harsh environment of the desert. Methods: The tears were collected from five camels, five male desert workers (20-25 years old) at a small village located 100 km from Riyadh, Saudi Arabia, and five male subjects (20-25 years old) from Riyadh. A small drop (1 μl) of tears was dried on a glass slide and observed under a light (Olympus BX1) and scanning electron microscope (Inspect S50, Field Electron and Ion Company [FEI]). Energy-dispersive X-ray spectroscopy (EDS) of the tear film and Refresh Plus were investigated with a JEOL 1400 scanning transmission electron microscope. Results: The camel tear film pattern was surrounded by thick, peripheral, homogenous layers containing small oily droplets, particles, and tiny branches in the tear ferning. The tear ferning of the camel was grade 0-1, whereas the tear ferning of human tears and Refresh Plus was grade 1-2. The mass percentage of chloride was highest in the camel tears. The mass percentage of potassium in the camel tears was greater than that in the human tears, but it was less than that in the Refresh Plus lubricant. Conclusions: Camel tears exhibit a better quality than human tears and Refresh Plus lubricant do. The presence of oily droplet-like structures at the periphery of tear ferning suggests that camel tear film may have a higher quality and quantity of minerals and lubricants, which may help the animal to avoid eye dryness. Future work is required to investigate the identification of the elements present in the peripheral and central part of the tear ferning.

Indexed as

AdultAnimalsCamelusCarboxymethylcellulose SodiumCations, MonovalentChloridesDry Eye SyndromesElectrolytesHumansLubricant Eye DropsMaleMicroscopyPotassiumSpectrometry, X-Ray EmissionTearsCarboxymethylcellulose SodiumCations, MonovalentChloridesElectrolytesLubricant Eye DropsPotassium

Identifiers

PMID29692599
PMCPMC5900468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.