ArticleIndian journal of dermatology
Conventional Versus Giant Basal Cell Carcinoma, a Review of 57 Cases: Histologic Differences Contributing to Excessive Growth.
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Giant basal cell carcinoma located in the temporal region: delay of the patient's visit because of COVID-19 pandemic.Postepy dermatologii i alergologii · 2025Article
- Basal cell skin cancer with metastasis to subcutaneous fat-a case report.Frontiers in surgery · 2025Article
- Article
- Resection of Skin Cancer Resulting in Free Vascularized Tissue Reconstruction: Always a Therapeutic Failure?Cancers · 2023Article
- Management of patients with giant basal cell carcinoma during SARS COV2 outbreak in Italy.Translational biophotonics · 2022Article
- Giant Mushroom-like Neglected Basal Cell Carcinoma of the Shoulder with Spontaneous Bleeding: A Successful Surgical Approach.European journal of case reports in internal medicine · 2021Article
- Basal Cell Carcinoma: A Patient and Physician's Experience.Dermatology and therapy · 2018Article
- Complex reconstruction of the orbitofrontal regions using three regional flaps after orbital exenteration for the treatment of basal cell carcinoma.Romanian journal of ophthalmologyArticle
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Authors and funding
4 authors.
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Abstract
backgroundGiant basal cell carcinoma (GBCC) is defined as a basal cell carcinoma (BCC) exceeding 5 cm in size. While these tumors impart significant morbidity due to local tissue destruction and have a higher rate of metastatic disease than their conventional (smaller) counterparts, reasons for their large size remain unclear. While theories relating to neglect or faster growth rate are often invoked; to date, there has not been a comprehensive evaluation of the histologic features of these large tumors that may contribute to their size.
methodsHistologic features of GBCCs (
resultsGBCCs, in addition to overall larger size, more often were thicker, displayed ulceration, and showed a more infiltrative growth pattern than their conventional counterparts. These rare tumors also displayed an insignificant increased propensity for a brisk host immune response, and the infiltrate significantly more often included clusters of plasma cells.
conclusionsMost histologic features seen in GBCCs likely reflect their large size. Histologic features alone are unlikely to explain the size of these rare tumors. The possibility of an altered host immune response contributing to the growth of these tumors requires further investigation.
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