Evidence map›Paper›PMID 29692333›Full record

ArticleTrends in endocrinology and metabolism: TEM2018

miR-33: A Metabolic Conundrum.

Anders M Näär

Abstract readComment
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Inhibition of miR-33a-5p in Macrophage-like Cells In Vitro Promotes apoAI-Mediated Cholesterol Efflux.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Anders M NäärHarvard Medical School and Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA, USA. Electronic address: naar@helix.mgh.harvard.edu.

Funding

T CELL SPECIFIC TRANSCRIPTION COMPLEXESP01GM047467 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAGNER, GERHARD · 1992 to 2017
$28.6M
A Thrifty MicroRNA in Insulin Resistance and Type 2 DiabetesR01DK114277 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI NAAR, ANDERS M · 2017 to 2019
$1.1M
NIDDK NIH HHS R01 DK114277NIGMS NIH HHS P01 GM047467
6 · The paper itself

Abstract

The miR-33 microRNAs (miRNAs) are crucial regulators of cholesterol/lipids, and may represent therapeutic targets for the treatment of atherosclerosis. A recent report by Price et al. showed that miR-33 knockout (KO) mice exhibit obesity, insulin resistance, and increased food intake, suggesting that metabolic regulation by miR-33 is more complex than was previously known.

Indexed as

Insulin ResistanceMicroRNAsAdiposityAnimalsMiceMice, KnockoutObesityTissue ExpansionMicroRNAsMirn33 microRNA, mouseinsulin resistancemicroRNAmiR-33obesity

Identifiers

PMID29692333
PMCPMC6151149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.