Evidence map›Paper›PMID 29691988›Full record

ReviewCNS neuroscience & therapeutics2018

Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment.

Igor Pomytkin, João P Costa-Nunes, Vladimir Kasatkin, Ekaterina Veniaminova, Anna Demchenko, Alexey Lyundup, Klaus-Peter Lesch, Eugene D Ponomarev, Tatyana Strekalova

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CNS neuroscience & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 4 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
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  3. Do oral antidiabetic medications alter the risk of Parkinson's disease? An updated systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023 · on this map
    Pooled it
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  7. Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  8. Hypothalamus-liver talks: whispers in the language of metabolism.Reviews in endocrine & metabolic disorders · 2026
    Review
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 5 countries.

Igor PomytkinDepartment of Advanced Cell Technologies, Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
João P Costa-NunesDepartment of Normal Physiology, Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.ORCID 0000-0003-0127-5420
Vladimir KasatkinDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Ekaterina VeniaminovaDepartment of Normal Physiology, Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
Anna DemchenkoDepartment of Advanced Cell Technologies, Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
Alexey LyundupDepartment of Advanced Cell Technologies, Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
Klaus-Peter LeschDepartment of Normal Physiology, Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
Eugene D PonomarevFaculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0002-0871-8522
Tatyana StrekalovaDepartment of Normal Physiology, Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.ORCID 0000-0001-9937-5600
Sechenov University · RUChinese University of Hong Kong · HKDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RUUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the insulin receptor (IR) was found in the CNS decades ago, the brain was long considered to be an insulin-insensitive organ. This view is currently revisited, given emerging evidence of critical roles of IR-mediated signaling in development, neuroprotection, metabolism, and plasticity in the brain. These diverse cellular and physiological IR activities are distinct from metabolic IR functions in peripheral tissues, thus highlighting region specificity of IR properties. This particularly concerns the fact that two IR isoforms, A and B, are predominantly expressed in either the brain or peripheral tissues, respectively, and neurons express exclusively IR-A. Intriguingly, in comparison with IR-B, IR-A displays high binding affinity and is also activated by low concentrations of insulin-like growth factor-2 (IGF-2), a regulator of neuronal plasticity, whose dysregulation is associated with neuropathologic processes. Deficiencies in IR activation, insulin availability, and downstream IR-related mechanisms may result in aberrant IR-mediated functions and, subsequently, a broad range of brain disorders, including neurodevelopmental syndromes, neoplasms, neurodegenerative conditions, and depression. Here, we discuss findings on the brain-specific features of IR-mediated signaling with focus on mechanisms of primary receptor activation and their roles in the neuropathology. We aimed to uncover the remaining gaps in current knowledge on IR physiology and highlight new therapies targeting IR, such as IR sensitizers.

Indexed as

AnimalsAntigens, CDBrainCentral Nervous System DiseasesHumansInsulinInsulin-Like Growth Factor INeuronal PlasticityProtein IsoformsReceptor, InsulinSignal TransductionTreatment OutcomeAntigens, CDINSR protein, humanInsulinInsulin-Like Growth Factor IProtein IsoformsReceptor, InsulinAlzheimer's diseasecentral nervous systeminsulin-like growth factor-2insulin receptorinsulin receptor sensitizersmitochondria

Identifiers

PMID29691988
PMCPMC6489906
OpenAlexW2802167103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.