ArticleHuman brain mapping2018
Functional connections between activated and deactivated brain regions mediate emotional interference during externally directed cognition.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial.Journal of psychiatric research · 2022Trial
- Inhibited neural response during interpersonal conflict: insights from fNIRS hyperscanning.Frontiers in psychology · 2025Article
- Changes in Spatiotemporal Dynamics of Default Network Oscillations between 19 and 29 Years of Age.Brain sciences · 2024Article
- The Influencing Mechanism of Incidental Emotions on Risk Perception: Evidence from Event-Related Potential.Brain sciences · 2023Article
- Testing the Magnitude of Correlations Across Experimental Conditions.Frontiers in psychology · 2022Article
- Brain network profiling defines functionally specialized cortical networks.Human brain mapping · 2018Article
- Functional connections between activated and deactivated brain regions mediate emotional interference during externally directed cognition.Human brain mapping · 2018Article
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Authors and funding
6 authors.
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Abstract
Recent evidence shows that task-deactivations are functionally relevant for cognitive performance. Indeed, higher cognitive engagement has been associated with higher suppression of activity in task-deactivated brain regions - usually ascribed to the Default Mode Network (DMN). Moreover, a negative correlation between these regions and areas actively engaged by the task is associated with better performance. DMN regions show positive modulation during autobiographical, social, and emotional tasks. However, it is not clear how processing of emotional stimuli affects the interplay between the DMN and executive brain regions. We studied this interplay in an fMRI experiment using emotional negative stimuli as distractors. Activity modulations induced by the emotional interference of negative stimuli were found in frontal, parietal, and visual areas, and were associated with modulations of functional connectivity between these task-activated areas and DMN regions. A worse performance was predicted both by lower activity in the superior parietal cortex and higher connectivity between visual areas and frontal DMN regions. Connectivity between right inferior frontal gyrus and several DMN regions in the left hemisphere was related to the behavioral performance. This relation was weaker in the negative than in the neutral condition, likely suggesting less functional inhibitions of DMN regions during emotional processing. These results show that both executive and DMN regions are crucial for the emotional interference process and suggest that DMN connections are related to the interplay between externally-directed and internally-focused processes. Among DMN regions, superior frontal gyrus may be a key node in regulating the interference triggered by emotional stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.