ArticleAddiction (Abingdon, England)2018
Testing associations between cannabis use and subcortical volumes in two large population-based samples.
Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03483220 (Relation Between Emotional Regulation and Impulsivity in Cannabis Use Disorder and the Morphometric Changes in Brain Reward System Structures), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relation Between Emotional Regulation and Impulsivity in Cannabis Use Disorder and the Morphometric Changes in Brain Reward System Structures
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Cumulative exposure to cannabis and hippocampus MRI in middle age: results from the coronary artery risk development in young adults (CARDIA) study.Translational psychiatry · 2026Article
- Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents.Behavior genetics · 2025Article
- Association Between Cannabis Use and Brain Structures: A Mendelian Randomization Study.Cureus · 2024Article
- Testing the consequences of alcohol, cannabis, and nicotine use on hippocampal volume: a quasi-experimental cotwin control analysis of young adult twins.Psychological medicine · 2023Article
- Diminished Structural Brain Integrity in Long-term Cannabis Users Reflects a History of Polysubstance Use.Biological psychiatry · 2022Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex: A comparison between early-onset smokers and late-onset smokers.Frontiers in psychiatry · 2022Article
- Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans.Human brain mapping · 2021Article
- Neuroanatomical Correlates of Impulsive Choices and Risky Decision Making in Young Chronic Tobacco Smokers: A Voxel-Based Morphometry Study.Frontiers in psychiatry · 2021Article
- Recent cannabis use is associated with smaller hippocampus volume: High-resolution segmentation of structural subfields in a large non-clinical sample.Addiction biology · 2021Article
- A unified framework for association and prediction from vertex-wise grey-matter structure.Human brain mapping · 2020Article
- Self-reported cognition and marijuana use in older adults: Results from the national epidemiologic survey on alcohol and related conditions-III.Addictive behaviors · 2020Article
- Association of antidepressants with brain morphology in early stages of psychosis: an imaging genomics approach.Scientific reports · 2019Article
- Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers.Psychiatry research. Neuroimaging · 2019Article
- Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives.The American journal of drug and alcohol abuse · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 8 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
aimsDisentangling the putative impact of cannabis on brain morphology from other comorbid substance use is critical. After controlling for the effects of nicotine, alcohol and multi-substance use, this study aimed to determine whether frequent cannabis use is associated with significantly smaller subcortical grey matter volumes.
designExploratory analyses using mixed linear models, one per region of interest (ROI), were performed whereby individual differences in volume (outcome) at seven subcortical ROIs were regressed onto cannabis and comorbid substance use (predictors).
settingTwo large population-based twin samples from the United States and Australia.
participantsA total of 622 young Australian adults [66% female; μ MEASUREMENTS: Magnetic resonance imaging (MRI) and volumetric segmentation methods were used to estimate volume in seven subcortical ROIs: thalamus, caudate nucleus, putamen, pallidum, hippocampus, amygdala and nucleus accumbens. Substance use measurements included maximum nicotine and alcohol use, total life-time multi-substance use, maximum cannabis use in the young adults and regular cannabis use in the middle-aged males.
findingsAfter correcting for multiple testing (P = 0.007), cannabis use was unrelated to any subcortical ROI. However, maximum nicotine use was associated with significantly smaller thalamus volumes in middle-aged males.
conclusionsIn exploratory analyses based on young adult and middle-aged samples, normal variation in cannabis use is unrelated statistically to individual differences in brain morphology as measured by subcortical volume.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.