Evidence map›Paper›PMID 29691757›Full record

ReviewProtein & cell2018

Microbiota transplantation: concept, methodology and strategy for its modernization.

Faming Zhang, Bota Cui, Xingxiang He, Yuqiang Nie, Kaichun Wu, Daiming Fan, FMT-standardization Study Group

6 registry-linked trialsAbstract readReview
In one paragraph

Review in Protein & cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 173 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03516461 narecruitingnot on this map

Efficacy and Safety of Fecal Microbiota Transplantation in Radiation Enteritis

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2018 to 2025Enrolled70ConditionsRadiation EnteritisArmsFecal Microbiota Transplantation (FMT)
NCT03764748 phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Washed Microbiota Transplantation for Tourette's Syndrome

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2024 to 2027Enrolled30ConditionsTourette SyndromeArmsWashed Microbiota Transplantation
NCT03895593 recruitingnot on this map

Rescue Fecal Microbiota Transplantation for Refractory Intestinal Infections: China National Registry

TypeobservationalSponsorThe Second Hospital of Nanjing Medical UniversityRan2015 to 2029Enrolled100ConditionsIntestinal Infection, Clostridioides Difficile Infection, Antibiotic-associated DiarrheaArmsrescue fecal microbiota transplantation
NCT05669651 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Multicenter, Prospective, Randomized Controlled Study to Explore the Efficacy and Safety of Fecal Microbiota Transplantation With Different Bacterial Doses in the Treatment of Recurrent Hepatic Encephalopathy

TypeinterventionalSponsorHainv GaoRan2022 to 2025Enrolled100ConditionsHepatic EncephalopathyArmsFecal Microbiota Transplantation
NCT06837194 recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy of WMT Combined With Nutritional Support in the Treatment of Malnutrition Complicated by Gastroptosis: A Real-World Study

Typeobservational_patient_registrySponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2027Enrolled24ConditionsGastroptosis, Malnutrition
NCT06844708 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

CMTS0929 for Inflammatory Bowel Disease: a Prospective, Open-label, Single-arm Clinical Study

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2030Enrolled12ConditionsInflammatory Bowel Disease (IBD)ArmsCMTS0929
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. [Fecal Microbiota Transplantation: A Promising Avenue for Lung Cancer Therapy].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
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  11. Therapeutic Evaluation ofNutrients · 2024
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Faming ZhangMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China. fzhang@njmu.edu.cn.ORCID 0000-0003-4157-1144
Bota CuiMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Xingxiang HeDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Yuqiang NieDepartment of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China.
Kaichun WuState Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
Daiming FanState Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
FMT-standardization Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gut-brain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future. Here, we review the changing concept of microbiota transplantation from FMT to selective microbiota transplantation, methodology development of FMT and step-up FMT strategy based on literature and state experts' perspectives.

Indexed as

Clostridium InfectionsFecal Microbiota TransplantationHost Microbial InteractionsHumansInflammatory Bowel DiseasesMetabolic DiseasesbacteriaClostridium difficileinflammatory bowel diseasemicrobiomeperspectivesselective microbiota transplantationstep-up fecal microbiota transplantation

Identifiers

PMID29691757
PMCPMC5960466

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.