ArticleScientific reports2018
A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- An Overview of Epidemiological Tools That Support the Progress of Foot-and-Mouth Disease Control in Southeast Asia.Pathogens (Basel, Switzerland) · 2026Review
- Article
- Prevalence and Serotype Distribution of Foot and Mouth Disease (FMD) Virus in Asian Countries: A Systematic Review and Meta-Analysis.Veterinary medicine international · 2026Review
- Recombination hotspots and genetic variability in foot-and-mouth disease virus genomes: a comparative genomic and phylogeographic analysis.Archives of virology · 2025Article
- Evaluation of applied foot and mouth disease-providing measures in the Republic of Armenia: A retrospective study.Open veterinary journal · 2025Article
- Foot-and-mouth disease in Armenia (1958-2003): Historical epidemiology, serotype dynamics, and evolving vaccination strategies.Veterinary world · 2025Article
- Epidemiology and economics of foot-and-mouth disease: current understanding and knowledge gaps.Veterinary research · 2025Review
- Differential mosaicism of recombinant foot-and-mouth disease viruses resulting from heterologous superinfection of cattle.Journal of virology · 2025Article
- A review of foot-and-mouth disease in Ethiopia: epidemiological aspects, economic implications, and control strategies.Virology journal · 2023Review
- Restraint of VP1 Protein of Foot and Mouth Disease Virus using Specific Antiviral Peptides: anArchives of Razi Institute · 2023Article
- Heterogeneity and Recombination of Foot-and-Mouth Disease Virus during Multi-Strain Coinfection of Cattle.mSphere · 2023Article
- Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation.Viruses · 2023Article
- Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement.Viruses · 2023Review
- Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains.Viruses · 2023Article
- Molecular detection, genetic diversity, and phylogenetic analysis of foot-and-mouth disease virus (FMDV) type O in Iran during 2015-2016.Iranian journal of veterinary research · 2023Article
- Evaluation of recombination detection methods for viral sequencing.Virus evolution · 2023Article
- Foot-and-mouth disease status in India during the second decade of the twenty-first century (2011-2020).Veterinary research communications · 2022Review
- Risk of transmission of foot-and-mouth disease by wild animals: infection dynamics in Japanese wild boar following direct inoculation or contact exposure.Veterinary research · 2022Article
- Foot-and-Mouth Disease Virus Interserotypic Recombination in Superinfected Carrier Cattle.Pathogens (Basel, Switzerland) · 2022Article
- Detection of clinical and subclinical Foot and Mouth Disease Virus in Cattle in Al-Najaf Province.Archives of Razi Institute · 2022Article
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination of rapidly evolving RNA-viruses provides an important mechanism for diversification, spread, and emergence of new variants with enhanced fitness. Foot-and-mouth disease virus (FMDV) causes an important transboundary disease of livestock that is endemic to most countries in Asia and Africa. Maintenance and spread of FMDV are driven by periods of dominance of specific viral lineages. Current understanding of the molecular epidemiology of FMDV lineages is generally based on the phylogenetic relationship of the capsid-encoding genes, with less attention to the process of recombination and evolution of non-structural proteins. In this study, the putative recombination breakpoints of FMDVs endemic to Southeast Asia were determined using full-open reading frame sequences. Subsequently, the lineages' divergence times of recombination-free genome regions were estimated. These analyses revealed a close relationship between two of the earliest endemic viral lineages that appear unrelated when only considering the phylogeny of their capsid proteins. Contrastingly, one lineage, named O/CATHAY, known for having a particular host predilection (pigs) has evolved independently. Additionally, intra-lineage recombination occurred at different breakpoints compared to the inter-lineage process. These results provide new insights about FMDV recombination patterns and the evolutionary interdependence of FMDV serotypes and lineages.
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