Evidence map›Paper›PMID 29691434›Full record

ArticleScientific reports2018

Global Similarity Method Based on a Two-tier Random Walk for the Prediction of microRNA-Disease Association.

Min Chen, Bo Liao, Zejun Li

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Min ChenCollege of Information Science and Engineering, Hunan University, Changsha, 410082, China.
Bo LiaoCollege of Information Science and Engineering, Hunan University, Changsha, 410082, China. dragonbw@163.com.
Zejun LiCollege of Information Science and Engineering, Hunan University, Changsha, 410082, China.
Hunan Institute of Technology · CNHunan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

microRNAs (miRNAs) mutation and maladjustment are related to the occurrence and development of human diseases. Studies on disease-associated miRNA have contributed to disease diagnosis and treatment. To address the problems, such as low prediction accuracy and failure to predict the relationship between new miRNAs and diseases and so on, we design a Laplacian score of graphs to calculate the global similarity of networks and propose a Global Similarity method based on a Two-tier Random Walk for the prediction of miRNA-disease association (GSTRW) to reveal the correlation between miRNAs and diseases. This method is a global approach that can simultaneously predict the correlation between all diseases and miRNAs in the absence of negative samples. Experimental results reveal that this method is better than existing approaches in terms of overall prediction accuracy and ability to predict orphan diseases and novel miRNAs. A case study on GSTRW for breast cancer and conlon cancer is also conducted, and the majority of miRNA-disease association can be verified by our experiment. This study indicates that this method is feasible and effective.

Indexed as

AlgorithmsBreast NeoplasmsComputational BiologyComputer SimulationForecastingGene Regulatory NetworksGenetic Predisposition to DiseaseHumansMicroRNAsMicroRNAs

Identifiers

PMID29691434
PMCPMC5915491
OpenAlexW2805950880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.