ArticleScientific reports2018
Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults.Age and ageing · 2023Pooled it
- Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.Cell reports. Medicine · 2022Pooled it
- Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.Nature communications · 2021Pooled it
- Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.Medicine and science in sports and exercise · 2026Article
- Integrative GWAS Catalog Analysis of Proxy-Trait Intersection in Sarcopenia-Related Musculoskeletal Aging with Multi-Criteria Evidence Integration.Life (Basel, Switzerland) · 2026Article
- From Athletic Performance to Functional Ageing: Shared Genetic Architecture, Redox-Inflammatory Pathways and Functional Reserve Across the Life Course-A Narrative Review.Biomedicines · 2026Review
- Article
- Colocalization and functional analyses identifyAmerican journal of physiology. Endocrinology and metabolism · 2026Article
- Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts.Annals of the New York Academy of Sciences · 2026Article
- Genome-wide association and integrative analyses of relative handgrip strength identify polygenic determinants of gastrointestinal disorder susceptibility.BMC gastroenterology · 2026Article
- BDNF coexpresses with MTOR and is associated with muscle fiber size, lean mass and power-related traits.European journal of applied physiology · 2025Article
- A multi-omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data.Experimental physiology · 2025Article
- Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study.Obesity (Silver Spring, Md.) · 2025Observational
- Biological Sex and the Association Between Grip Strength and Cardiovascular Disease: a Scoping Review.Canadian geriatrics journal : CGJ · 2025Review
- Genetic Liability to Higher Muscle Strength Associates With a Lower Risk of Cardiovascular Disease Mortality in Men Irrespective of Leisure-Time Physical Activity in Adulthood: A Longitudinal Cohort Study.Journal of the American Heart Association · 2025Article
- Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.American journal of translational research · 2025Article
- TheMetabolites · 2024Article
- Unpicking Causal Relationships Between Grip Strength and Cardiorespiratory Fitness: A Bidirectional Mendelian Randomization Study.Scandinavian journal of medicine & science in sports · 2024Article
- Testing in Football: A Narrative Review.Sports (Basel, Switzerland) · 2024Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our discovery analysis of 223,315 individuals, we identified 101 loci associated with grip strength (P <5 × 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.