Evidence map›Paper›PMID 29691401›Full record

ArticleNature communications2018

Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4

Feng Leng, Jiekai Yu, Chunxiao Zhang, Salvador Alejo, Nam Hoang, Hong Sun, Fei Lu, Hui Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Feng LengDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA.
Jiekai YuDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA.
Chunxiao ZhangDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA.
Salvador AlejoDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA.ORCID http://orcid.org/0000-0002-1390-9892
Nam HoangDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA.
Hong SunDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA.
Fei LuSchool of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.ORCID http://orcid.org/0000-0001-5086-1157
Hui ZhangDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV89154, USA. hui.zhang@unlv.edu.ORCID http://orcid.org/0000-0001-6028-2554
University of Nevada, Las Vegas · USPeking University · CN

Funding

Novel Regulation of Receptor Tyrosine Kinases by ASM (Acidic Sphingomyelinase)R15NS096694 · NINDS · UNIVERSITY OF NEVADA LAS VEGAS · PI SUN, HONG · 2016 to 2016
$428k
Control of Epigenetic Inheritance By ProteolysisR15GM116087 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI ZHANG, HUI · 2015 to 2015
$362k
NIGMS NIH HHS R15 GM116087NINDS NIH HHS R15 NS096694
6 · The paper itself

Abstract

Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves epigenetic inheritance of DNA methylation patterns during DNA replication, is demethylated by LSD1. A novel methyl-binding protein, L3MBTL3, binds the K142-methylated DNMT1 and recruits a novel CRL4

Indexed as

Amino Acid MotifsAnimalsDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA MethylationE2F1 Transcription FactorFemaleGene DeletionHistone DemethylasesHumansIntracellular Signaling Peptides and ProteinsMaleMethylationMiceProtein BindingProtein StabilityCRL4 E3 ubiquitin ligase complex, mouseDcaf5 protein, mouseDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, mouseE2f1 protein, mouseE2F1 Transcription FactorHistone DemethylasesIntracellular Signaling Peptides and ProteinsKDM1a protein, mouseMBT-1 protein, mouseUbiquitin-Protein Ligase Complexes

Identifiers

PMID29691401
PMCPMC5915600
OpenAlexW2802116908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.