Evidence map›Paper›PMID 29691298›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2.

Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 81 citations in OpenAlex.

  1. A Microdosing Study withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Trial
  2. Article
  3. Review
  4. Carbonic Anhydrase Inhibitors in Oncology.Sub-cellular biochemistry · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Targeted interleukin-2 enhances the in vivo anti-cancer activity of Pluvicto™.European journal of nuclear medicine and molecular imaging · 2024
    Article
  13. CA IX-targeted AgJournal of pharmaceutical analysis · 2024
    Article
  14. Review
  15. Review
  16. Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  17. Review
  18. Optimizing the enzymatic release of MMAE fromFrontiers in pharmacology · 2023
    Article
  19. Frontiers in pharmacology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Samuele Cazzamalli *Department of Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland.ORCID 0000-0003-0510-5664
Barbara Ziffels *Department of Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland.
Fontaine WidmayerDepartment of Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland.
Patrizia MurerDepartment of Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland.
Giovanni PellegriniLaboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland.
Francesca PrettoPhilochem AG, Libernstrasse 3, Otelfingen, Switzerland.
Sarah WulhfardPhilochem AG, Libernstrasse 3, Otelfingen, Switzerland.
Dario NeriDepartment of Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland. dario.neri@pharma.ethz.ch.
ETH Zurich · CHPhilochem (Switzerland) · CHUniversity of Zurich · CH

Funding

European Research Council 670603Swiss National Science Foundation 163479
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntigens, NeoplasmCarbonic Anhydrase IXCarcinoma, Renal CellCell Line, TumorCell ProliferationColorectal NeoplasmsDisease Models, AnimalGene Expression Regulation, NeoplasticHumansImmunotherapyInterleukin-2LigandsMiceMolecular Targeted TherapyPeptidesAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase IXInterleukin-2LigandsPeptidesSmall Molecule Libraries

Identifiers

PMID29691298
PMCPMC6126628
OpenAlexW2802217282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.