Evidence map›Paper›PMID 29691296›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma.

Pravin Kesarwani, Antony Prabhu, Shiva Kant, Praveen Kumar, Stewart F Graham, Katie L Buelow, George D Wilson, C Ryan Miller, Prakash Chinnaiyan

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 74 citations in OpenAlex.

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  16. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity.Journal of experimental & clinical cancer research : CR · 2023
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Pravin KesarwaniDepartment of Radiation Oncology, Beaumont Health, Royal Oak, Michigan.
Antony PrabhuDepartment of Radiation Oncology, Beaumont Health, Royal Oak, Michigan.
Shiva KantDepartment of Radiation Oncology, Beaumont Health, Royal Oak, Michigan.
Praveen KumarMetabolomics and Obstetrics/Gynecology, Beaumont Research Institute, Beaumont Health, Royal Oak, Michigan.
Stewart F GrahamMetabolomics and Obstetrics/Gynecology, Beaumont Research Institute, Beaumont Health, Royal Oak, Michigan.
Katie L BuelowDepartment of Radiation Oncology, Beaumont Health, Royal Oak, Michigan.
George D WilsonDepartment of Radiation Oncology, Beaumont Health, Royal Oak, Michigan.
C Ryan MillerDepartment of Pathology & Laboratory Medicine, Neurology, & Pharmacology, Lineberger Comprehensive Cancer Center and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.ORCID 0000-0002-0096-8762
Prakash ChinnaiyanDepartment of Radiation Oncology, Beaumont Health, Royal Oak, Michigan. prakash.chinnaiyan@beaumont.edu.
Beaumont Health · USOakland University · USUniversity of North Carolina at Chapel Hill · US

Funding

Credentialing murine models for glioblastoma preclinical drug developmentR01CA204136 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERENS, MICHAEL E., JOHNSON, GARY L. · 2017 to 2019
$1.8M
Developing therapeutic strategies to elicit metabolic synthetic lethality in glioblastomaR01NS110838 · NINDS · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI CHINNAIYAN, PRAKASH · 2020 to 2024
$1.7M
Biologic consequence and therapeuticimplications of cysteine catabolism in glioblastomaR21NS090087 · NINDS · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI CHINNAIYAN, PRAKASH · 2016 to 2017
$418k
NCI NIH HHS R01 CA204136NINDS NIH HHS R01 NS110838NINDS NIH HHS R21 NS090087
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell Cycle CheckpointsCell Line, TumorEnzyme InhibitorsGene Expression Regulation, NeoplasticGlioblastomaHumansImidazolesIndoleamine-Pyrrole 2,3,-DioxygenaseIndolesMetabolomicsMiceRadiotherapyT-Lymphocytes, RegulatoryTryptophanXenograft Model Antitumor AssaysEnzyme InhibitorsIDO1 protein, humanImidazolesIndoleamine-Pyrrole 2,3,-DioxygenaseIndolesnavoximodTryptophan

Identifiers

PMID29691296
PMCPMC6591719
OpenAlexW2801543695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.