ArticleJournal of epidemiology and community health2018
Cognitive function trajectories and their determinants in older people: 8 years of follow-up in the English Longitudinal Study of Ageing.
Article in Journal of epidemiology and community health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 5 of them syntheses that pooled it.
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Who cites it
158 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS.The American journal of clinical nutrition · 2024Pooled it
- Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review.BMC geriatrics · 2022Pooled it
- Phototherapy for Cognitive Function in Patients With Dementia: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age.Nature communications · 2019Pooled it
- Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial.The American journal of clinical nutrition · 2024Trial
- Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Trial
- The developmental trajectories of executive function from adolescence to old age.Scientific reports · 2021Trial
- Growth mindset and grit as psychological resources in later life: age, socioeconomic status, and health patterning in the English Longitudinal Study of Ageing.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults.bioRxiv : the preprint server for biology · 2026Article
- Long-term reliability and stability of parameterized resting state EEG: evidence from a five-year follow-up.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Age-Related Differences in Ocular and Cardiovascular Responses and Recovery After Graded Motor-Cognitive Physical Activity.Healthcare (Basel, Switzerland) · 2026Article
- Association between becoming a carer in later life and changes in the trajectory of cognitive function: results from the English longitudinal study of ageing.Age and ageing · 2026Article
- Markers of left atrial cardiopathy and cognitive function trajectories in adults aged ≥ 45 years without atrial fibrillation: a population-based study.BMC neurology · 2026Article
- Physical activity and sedentary behavior patterns in cognitive impairment: findings from a cross-sectional study in Punjab, North India.BMC public health · 2026Article
- Proteomics signatures associated with cognitive trajectories: evidence from the English Longitudinal Study of Ageing.medRxiv : the preprint server for health sciences · 2026Article
- Polygenic scores for executive functioning as predictors of performance improvements after repeated testing in major psychiatric disorders.Scientific reports · 2026Article
- Effects of sarcopenia on cognitive function in middle-aged and older adults: mediating roles of social participation and instrumental activities of daily living disability.BMC public health · 2026Article
- The decline in cognitive function with age and its changes over time in cognitively normal older adults.European geriatric medicine · 2026Article
- Neighborhood Disadvantage, Functional Difficulty, and Cognitive Decline among Older Mexican Americans.Journal of racial and ethnic health disparities · 2026Article
98 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
backgroundMaintaining cognitive function is an important aspect of healthy ageing. In this study, we examined age trajectories of cognitive decline in a large nationally representative sample of older people in England. We explored the factors that influence such decline and whether these differed by gender.
methodsLatent growth curve modelling was used to explore age-specific changes, and influences on them, in an 8-year period in memory, executive function, processing speed and global cognitive function among 10 626 participants in the English Longitudinal Study of Ageing. We run gender-specific models with the following exposures: age, education, wealth, childhood socioeconomic status, cardiovascular disease, diabetes, physical function, body mass index, physical activity, alcohol, smoking, depression and dementia.
resultsAfter adjustment, women had significantly less decline than men in memory (0.011, SE 0.006), executive function (0.012, SE 0.006) and global cognitive function (0.016, SE 0.004). Increasing age and dementia predicted faster rates of decline in all cognitive function domains. Depression and alcohol consumption predicted decline in some cognitive function domains in men only. Poor physical function, physical inactivity and smoking were associated with faster rates of decline in specific cognitive domains in both men and women. For example, relative to study members who were physically active, the sedentary experienced greater declines in memory (women -0.018, SE 0.009) and global cognitive function (men -0.015, SE 0.007 and women -0.016, SE 0.007).
conclusionsThe potential determinants of cognitive decline identified in this study, in particular modifiable risk factors, should be tested in the context of randomised controlled trials.
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